名古屋大学生物機能開発利用研究センター 動物器官機能研究分野(理学部生命理学専攻 動物器官機能学研究グループ)

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[ 原著論文 ] , [ 総説 ]

原著論文

  • Matsuda, K., Yoshida, M., Kawakami, K., Hibi, M. and Shimizu, T.
    Granule cells control recovery from classical conditioned fear responses in the zebrafish cerebellum.
    Sci Rep 7, 11865 (2017)
  • Takeuchi, M., Inoue, C., Goshima, A., Nagao, Y., Shimizu, K., Miyamoto, H., Shimizu, T., Hashimoto, H., Yonemura, S., Kawahara, A., Hirata, Y., Yoshida, M., and Hibi, M.
    Medaka and zebrafish contactin1 mutants as a model for understanding neural circuits for motor coordination.
    Genes Cells 22, 723-741 (2017)
  • Yun, U.J., Sung, J.Y., Park, S.Y., Ye, S.K., Shim, J., Lee, J.S., Hibi, M., Bae, Y.K., and Kim, Y.N.
    OOncogenic role of rab escort protein 1 through EGFR and STAT3 pathway.
    Cell Death Dis. 8, e2621 (2017)
  • Song, K.H., Woo, S.R., Chung, J.Y., Lee, H.J., Oh, S.J., Hong, S.O., Shim, J., Kim, Y.N., Rho, S.B., Hong, S.M., Cho, H., Hibi, M.., Bae, D.J., Kim, S.Y., Kim, M.G., Kim, T.W., and Bae, Y.K.
    REP1 inhibits FOXO3-mediated apoptosis to promote cancer cell survival.
    Cell Death Dis. 8, e2536 (2017)
  • Chiba, A., Watanabe-Takano, H., Terai, K., Fukui, H., Miyazaki, T., Uemura, M., Hashimoto, H., Hibi, M., Fukuhara, S., and Mochizuki, N.
    Biochemical characterization of the medaka (Oryzias latipes) orthologue for mammalian tissue-type transglutaminase (TG2).
    Development 144, 334-344 (2017)
  • Takeuchi, M., Yamaguchi, S., Sakakibara, Y., Hayashi, T., Matsuda, K., Hara, Y., Tanegashima, C., Shimizu, T., Kuraku, S., and Hibi, M.
    Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum.
    J. Comp. Neurol. 525, 1558-1585 (2017)
  • Scalise, K., Shimizu, T., Hibi, M., and Sawtell, NB.
    Responses of cerebellar Purkinje cells during fictive optomotor behavior in larval zebrafish.
    J. Neurophysiol. 116, 2067-2080 (2016)
  • Kim, JD., Park, KE., Ishida, J., Kako, K., Hamada, J., Kani, S., Takeuchi, M., Namiki, K., Fukui, H., Fukuhara, S., Hibi, M., Kobayashi, M., Kanaho, Y., Kasuya, Y., Mochizuki, N., and Fukamizu, A.
    PRMT8 as a phospholipase regulates Purkinje cell dendritic arborization and motor coordination.
    Sci. Adv. 1, e1500615 (2015)
  • Takeuchi, M., Yamaguchi, S., Yonemura, S., Kakiguchi, K., Sato, Y., Higashiyama, T, Shimizu, T., and Hibi, M.
    Type IV Collagen Controls the Axogenesis of Cerebellar Granule Cells by Regulating Basement Membrane Integrity in Zebrafish.
    PLoS Genet. 11, e1005587 (2015)
  • Takeuchi, M., Matsuda, K., Yamaguchi, S., Asakawa, K., Miyasaka, N., Lal, P. Yoshihara, Y., Koga, A., Kawakami, K., Shimizu, T., and Hibi, M.
    Establishment of Gal4 transgenic zebrafish lines for analysis of development of cerebellar neural circuitry.
    Dev. Biol. 397, 1-17 (2015)
  • Nagao, Y., Suzuki, T., Shimizu, A., Kimurata, T., Seki, R., Adachi, T., Inoue, C., Omae, Y., Kamei, Y., Hara, I., Taniguchi, Y., Naruse, K., Wakamatsu, Y., Kelsh, R.N. Hibi, M., and Hashimoto, H.
    Sox5 functions as a fate switch in medaka pigment cell development.
    PLoS Genet. 10, e1004246 (2014)
  • Kwon, H.B., Fukuhara, S., Asakawa, K., Ando, K., Kashiwada, T., Kawakami, K., Hibi, M., Kwon, Y.G., Kim, K.W., Alitalo, K., and Mochizuki, N.
    The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc/Vegfr3 signaling in zebrafish.
    Development 140, 4081-4090 (2013)
  • Yanicostas, C., Barbieri, E., Hibi, M., Brice, A., Stevanin, G., and Soussi-Yaniscostas, N.
    Requirement for zebrafish ataxin-7 in differentiation of photoreceptors and cerebellar neurons.
    PLoS One 7, e50705 (2012)
  • Tran, L.D., Hino, H., Quach, H., Lim, S., Shindo, A., Mimori-Kiyosue, Y., Mione, M., Ueno, N., Winkler, C., Hibi, M., and Sampath, K.
    Dynamic microtubules at the vegetal cortex predict the embryonic axis in zebrafish.
    Development 139, 3644-3652 (2012)
  • Kuscha, V., Frazer, S.L., Dias, T.B., Hibi, M., Becker, T., and Becker, C.G.
    Lesion-induced generation of interneuron cell types in specific dorsoventral domains in the spinal cord of adult zebrafish.
    J. Comp. Neurol. 520, 3604-3616 (2012)
  • Moriyama, Y., Kawanishi, T., Nakamura, R., Tsukahara, T., Sumiyama, K., Suster, M.L., Kawakami, K., Toyada, A., Fujiyama, A., Yasuoka, Y., Nagao, Y. Sawatari, E., Shimizu, A., Wakamatsu, Y., Hibi, M., Taira, M., Okabe, M., Naruse, K., Hashimoto, H., Shimada, A., and Takeda, H.
    The medaka zic1/zic4 mutant provides molecular insights into teleost caudal fin evolution.
    Curr. Biol. 22, 601-607 (2012)
  • Imai, H., Oomiya, Y., Kikkawa, S., Shoji, W., Hibi, M., Terashima, T., and Katsuyama, Y.
    Dynamic changes in the gene expression of zebrafish Reelin receptors during embryogenesis and htaching period.
    Dev. Growth Differ. 54, 53-263 (2012)
  • Takano, A., Zochi, R., Hibi, M., Terashima, T., and Katsuyama, Y.
    Function of strawberry notch family genes in the zebrafish brain develoment.
    Kobe J. Med. Sci. 56, E220-E230 (2011)
  • Tanabe, K., Kani, S., Shimizu, T., Bae, Y.-K., Abe, T., and Hibi, M.
    Atypical PKC regulates primary dendrite specification of cerebellar Purkinje cells by localizing Golgi apparatus.
    J. Neurosci. 30, 16983-16992 (2010)
  • Nagao, Y., Cheng, J., Kamura, K., Seki, R., Maeda, A., Nihei, D., Koshida, S., Wakamatsu, Y., Fujimoto, T., Hibi, M., and Hashimoto, H.
    Dynein axonemal intermediate chain 2 is required for formation of the left-right body axis and kidney in medaka.
    Dev. Biol. 347, 53-61 (2010)
  • Takano, A., Zochi, R., Hibi, M., Terashima, T., and Katsuyama, Y.
    Expression of strawberry notch family genes during zebrafish embryogenesis.
    Dev. Dyn. 239, 1789-1796 (2010)
  • Kani, S., Bae, Y.-K., Shimizu, T., Tanabe, K., Satou, C., Parsons, M.J. Scott, E., Higashijima, S.-I., and Hibi, M.
    Proneural gene-linked neurogenesis in zebrafish cerebellum.
    Dev. Biol. 343, 1-17 (2010)
  • Shimizu, T., Nakazawa, M., Kani, S., Bae, Y.-K., Shimizu, T., Kageyama, R., and Hibi, M.
    Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in forebrain.
    Development 137, 1875-1885 (2010)
  • Nojima, H., Rothhämel, S., Shimizu, T., Kim, C.H., Yonemura, S., Marlow, F.L., and Hibi, M.
    Syntabulin, a motor protein linker, controls dorsal determination.
    Development 137, 923-933 (2010)
  • Bae, Y.-K., Kani, S., Shimizu, T., Tanabe, K., Nojima, H., Kimura, Y., Higashijima, S.-I., and Hibi, M.
    Anatomy of zebrafish cerebellum and screen for mutations affecting its development.
    Dev. Biol. 330, 406-426 (2009)
  • Kim, H., Kim, S., Chung, A.Y., Bae, Y.K., Hibi, M., Lim, C.S., and Park, H.C.
    Notch-regulated perineurium development from zebrafish spinal cord.
    Neurosci. Lett. 448, 240-244 (2008)
  • Asakawa, K., Suster, M. L., Mizusawa, K., Nagayoshi, S., Kotani, T., Urasaki, A., Kishimoto, Y., Hibi, M., and Kawakami, K.
    Genetic dissection of neural circuits by Tol2 transposon-mediated Gal4 gene and enhancer trapping in zebrafish.
    Proc. Natl. Acad. Sci. USA. 105, 1255-1260 (2008)
  • Katsuyama, Y., Oomiya, Y., Dekimoto, H., Motooka, E., Takano, A., Kikkawa, S., Hibi, M., and Terashima, T.
    Expression of zebrafish ROR alpha gene in cerebellar-like structures.
    Dev. Dyn. 236, 2694-2701 (2007)
  • Nikaido, M., Doi, K., Shimizu, T., Hibi, M., Kikuchi, Y., and Yamasu, K.
    Initial specification of the epibranchial placode in zebrafish embryos depends on the fibroblast growth factor signal.
    Dev. Dyn. 236, 564-571 (2007)
  • Komuta, Y., Hibi, M., Arai, T., Nakamura, S., and Kawano, H.
    Defects in reciprocal projects between the thalamus and cerebral cortex in the early development of Fezl-deficient mice.
    J. Comp. Neurol. 503, 454-465 (2007)
  • Shimizu, T., Bae, Y.-K., and Hibi, M.
    Cdx-Hox code controls competence for responding to Fgfs and retinoic acid in zebrafish neural tissue.
    Development 133, 4709-4719 (2006)
  • Hirata, T., Nakazawa, M., Muraoka, O., Nakayama, R., Suda, Y., and Hibi, M.
    Zinc-finger genes Fez and Fez-like function in the establishment of diencephalon subdivisions.
    Development 133, 3993-4004 (2006)
  • Hirata, T., Nakazawa, M., Yoshihara, S., Miyachi, H., Kitamura, K., Yoshihara, Y., and Hibi, M.
    Zinc-finger gene Fez in the olfactory neurons regulates development of the olfactory bulb non-cell-autonomously.
    Development 133, 1433-1443 (2006)
  • Muraoka, O., Shimizu, T., Yabe, T., Nojima, H., Bae, Y-K., Hashimoto, H., and Hibi, M.
    Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein.
    Nat. Cell Biol. 8, 329-340 (2006)
  • Molyneaux, B.J., Arlotta, P., Hirata, T., Hibi, M., and Macklis J.D.
    Fezl is required for the birth and specification of corticospinal motor neurons.
    Neuron 47, 817-831 (2005)
  • Shimizu, T., Yabe, T., Muraoka, O., Yonemura, S., Aramaki, S., Hatta, K., Bae, Y.-K., Nojima, H., and Hibi, M.
    E-cadherin is required for gastrulation cell movements in zebrafish.
    Mech. Dev. 122, 747-763 (2005)
  • Bae, Y-K., Shimizu, T., and Hibi, M.
    Patterning of proneuronal and inter-proneuronal domains by hairy- and enhancer of split-related genes in zebrafish neuroectoderm.
    Development 132, 1375-1385 (2005)
  • Shimizu, T., Bae, Y.-K., Muraoka, O., and Hibi, M.
    Interaction of Wnt and caudal-related genes in zebrafish posterior body formation.
    Dev. Biol. 279, 125-141 (2005)
  • Yamamoto, A., Nagano, T., Takehara, S., Hibi, M., and Aizawa, S.
    Shisa promotes head formation through the inhibition of receptor maturation for the caudalizing factors, Wnt and FGF.
    Cell 120, 223-235 (2005)
  • Nojima, H., Shimizu, T. , Kim, C.-H., Yabe, T., Bae, Y.-K., Muraoka, O., Hirata, T., Chitnis, A., Hirano, T., and Hibi, M.
    Genetic evidence for involvement of maternally derived Wnt canonical pathway in dorsal determination in zebrafish.
    Mech. Dev. 121, 371-386 (2004)
  • Hirata, T., Suda, Y., Nakao, K., Narimatsu, M., Hirano, T., and Hibi, M.
    The zinc finger gene fez-like functions in the formation of subplate neurons and thalamocortical axons.
    Dev. Dyn. 230, 546-556 (2004)
  • Hashimoto, H., Rebagliati, M., Ahmad, N., Muraoka, O., Kurokawa, T., Hibi, M.* and Suzuki, T.*
    The Cerberus/Dan-family protein Charon is a negative regulator of Nodal signaling during left-right patterning in zebrafish.
    Development 131, 1741-1753 (2004)*corresponding authors.
  • Bae, Y.-K., Shimizu, T., Muraoka, O., Yabe, T., Hirata, T., Nojima, H., Hirano, T., and Hibi, M.
    Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish.
    Gene Expr. Patterns 4, 481-486 (2004)
  • Yabe, T., Shimizu, T., Muraoka, O., Bae, Y.-K., Hirata, T., Nojima, H., Kawakami, A., Hirano, T., and Hibi, M.
    Ogon/Secreted Frizzled functions as a negative feedback regulator of BMP signaling.
    Development 130, 2705-2716 (2003)
  • Bae, Y.-K., Shimizu, T., Yabe, T., Kim, C.-H., Hirata, T., Nojima, H., Muraoka, O., Hirano, T., and Hibi, M.
    A homeobox gene, pnx, is involved in the formation of posterior neurons in zebrafish.
    Development 130, 1853-1865 (2003)
  • Yamasaki, S., Nishida, K., Yoshida, Y., Itoh, M., Hibi, M., and Hirano, T.
    Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2.
    Oncogene 22, 1546-1556 (2003)
  • Levkowitz, G., Zeller, J., Sirotkin, H.I., French, D., Schilbach, S., Hashimoto, H., Hibi, M., Talbot, W.S., and Rosenthal, A.
    Zinc finger protein too few controls the development of monoaminergic neurons.
    Nat. Neurosci.6, 28-33 (2003)
  • Shimizu, T., Yamanaka, Y., Nojima, H., Yabe, T., Hibi, M., and Hirano, T.
    A novel repressor-type homeobox gene, ved, is involved in dharma/bozozok-mediated dorsal organizer formation in zebrafish.
    Mech. Dev. 118, 125-138 (2002)
  • Itoh, S., Itoh, M., Nishida, K., Yamasaki, S., Yoshida, Y., Narimatsu, M., Park, J.P., Hibi, M., Ishihara, K., and Hirano, T.
    Adapter molecule Grb2-associated binder 1 is specifically expressed in marginal zone B cells and negatively regulates thymus-independent antigen-2 responses.
    J. Immunol. 168, 5110-5116 (2002)
  • Nishida, K., Wang, L., Mori, E., Park, S-J., Narimatsu, M., Itoh, S., Yamasaki, S., Fujishima, M., Ishihara, K., Hibi, M., Kitamura, Y., and Hirano, T.
    Requirement of Gab2 for mast cell development and Kitl/c-Kit signaling.
    Blood 99,1866-1869 (2002)
  • Yamada, K., Nishida, K., Hibi, M., Hirano, T., and Matsuda, Y.
    Comparative FISH mapping of Gab1 and Gab2 genes in human, mouse, and rat.
    Cytogenet Cell Genet. 94, 39-42 (2001)
  • Yamasaki, S., Nishida, K., Hibi, M., Sakuma, M., Shiina, R., Takeuchi, A., Ohnishi, H., Hirano, T., and Saito, T.
    Docking protein Gab2 is phosphorylated by ZAP70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules.
    J. Biol. Chem. 276, 45175-45183 (2001)
  • Narimatsu, M., Maeda, H., Itoh, S., Atsumi, T., Ohtani, T., Nishida, K., Itoh, M., Kamimura, D., Park, SJ., Mizuno, K., Miyazaki, Ji., Hibi, M., Ishihara, K., Nakajima, K., and Hirano, T.
    Tissue-specific autoregulation of the stat3 gene and its role in interleukin-6-induced survival signals in T cells.
    Mol Cell Biol. 21, 6615-6625 (2001)
  • Kojima, H., Shinagawa, A., Shimizu, S., Kanada, H., Hibi, M., Hirano, T., and Nagasawa, T.
    Role of phosphatidylinositol-3 kinase and its association with Gab1 in thrombopoietin-mediated up-regulation of platelet function.
    Exp Hematol. 29, 616-622 (2001)
  • Mizuno, K., Shirogane, T., Shinohara, A., Iwamatsu, A., Hibi, M., and Hirano, T.
    Regulation of Pim-1 by Hsp90.
    Biochem Biophys Res Commun. 281, 663-669 (2001)
  • Ryu, S-L., Fujii, R., Yamanaka, Y., Shimizu, T., Yabe, T., Hirata, T., Hibi, M., and Hirano, T.
    Regulation of dharma/bozozok by the Wnt pathway.
    Dev. Biol. 231, 397-409 (2001)
  • Muraoka, O., Ichikawa, H., Shi, H., Okamura, S., Taira, E., Higuchi, H., Hirano, T., Hibi, M., and Miki, N.
    Kheper, a novel ZFH/dEF1 family, regulates the development of the neuroectoderm of zebrafish (Danio rerio).
    Dev. Biol. 228, 29-40 (2000)
  • Park, H-C., Kim, C-H., Bae, Y-K., Yeo, S-Y., Kim, S-H., Hong, S-K., Shin, J., Hibi, M., Hirano, T., Miki, N., Chitnis, A.B., and Huh, T-L.
    Analysis of upstream elements in the HuC promoter leads to the establishment of transgenic zebrafish with fluorescent neurons.
    Dev. Biol. 227, 279-293 (2000)
  • Fujii, R., Yamashita, S., Hibi, M., and Hirano, T.
    Asymmetric p38 activation in zebrafish; its possible role in symmetric and synchrnous cleavage.
    J. Cell. Biol. 150, 1335-1347 (2000)
  • Hashimoto H., Yabe, T., Hirata, T., Shimizu, T., Bae, Y.-K., Yamanaka, Y., Hirano, T., and Hibi, M.
    Expression of the zinc finger gene fez-like in zebrafish forebrain.
    Mech. Dev. 97, 191-195 (2000)
  • Hirata, T., Yamanaka, Y., Ryu, S.-L., Shimizu, T., Yabe, T., Hibi, M., and Hirano, T.
    Novel mix-family homeobox genes in zebrafish and their differential regulation.
    Biochem. Biophys. Res. Commun. 271, 603-609 (2000)
  • Itoh, M., Yoshida, Y., Nishida, K., Narimatsu, M., Hibi, M., and Hirano, T.
    A role of Gab1 for heart, placenta, and skin development, and growth factors- and cytokines-induced ERK MAP kinase activation.
    Mol. Cell. Biol. 20, 3695-3704 (2000)
  • Daino, H., Matsumura, I., Takeda, K., Oajima, J., Tanaka, H., Ueda, S., Shibayama, H., Ikeda, H., Hibi, M., Hirano, T., and Kanakura, Y.
    Induction of apoptosis by extracellular ubiquitin in human hematopoietic cells: possible involvement of STAT3 degradation by proteasome pathway in interleuikin 6-dependent hematopoietic cells. Blood 95, 2577-2585 (2000)
  • Shimizu, T., Yamanaka, Y., Ryu, S-L., Hashimoto, H., Yabe, T., Hirata, T., Bae, Y-K., Hibi, M., and Hirano, T.
    Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish.
    Mech. Dev. 91, 293-303 (2000)
  • Ohtani, T., Ishihara, K., Atsumi, T., Nishida, K., Kaneko, Y., Miyata, T., Itoh, S., Narimatsu, M., Maeda, H., Fukada, T., Itoh, M., Okano, H., Hibi, M., and Hirano, T.
    Dissection of signaling cascades through gp130 in vivo: Reciprocal roles for STAT3- and SHP2-mediated signals in immune responses.
    Immunity12, 95-105 (2000)
  • Hashimoto, H., Itoh, M., Yamanaka, Y., Yamashita, S., Shimizu, T., Solnica-Krezel, L., Hibi, M., and Hirano, T.
    Zebrafish Dkk1 functions in Forebrain Specification and Axial Mesendoderm Formation.
    Dev. Biol. 217, 138-152 (2000)
  • Shirogane, T., Fukada, T., Muller, J.M.M., Shima, D.T., Hibi, M., and Hirano, T.
    Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and anti-apoptosis. Immunity 11, 709-719 (1999)
  • Ito, M., Yoshioka, K., Akechi, M., Yamashita, S., Takamatsu, N., Sugiyama, K., Hibi, M., Nakabeppu, Y., Shiba, T., and Yamamoto, K-i.
    JSAP1, a novel JNK-binding protein that functions as a scaffolding factor in the JNK signaling pathway.
    Mol. Cell. Biol. 19, 7539-7548 (1999)
  • Nakayama, K., Hara, T., Hibi, M., Hirano, T., and Miyajima, A.
    A novel oncostatin M-inducible gene OIG37 forms a gene family with MyD118 and GADD45 and negatively regulates cell growth.
    J. Biol. Chem. 274, 24766-24772 (1999)
  • Wickrema, A., Uddin, S., Sharma, A., Chen, F., Alsayed, Y., Ahmad, S., Sawyer, S.T., Krystal, G., Yi, T., Nishada, K., Hibi, M., Hirano, T., and Platanias. L.C.
    Engagement of gab1 and gab2 in erythropoietin signaling.
    J. Biol. Chem. 274, 24469-24474 (1999)
  • Fekany, K., Yamanaka, Y., Leung, T., Sirotkin, H. I., Topczewski, J., Gates, M. A., Hibi, M., Renucci, A., Stemple, D., Radbill, A., Schier, A. F., Driever, W., Hirano, T., Talbot, W. S., and Solnica-Krezel, L.
    The zebrafish bozozok locus encodes Dharma, a hemoedomain protein essential for induction of gastrula organizer and dorsoanterior embryonic structures.
    Development 126, 1427-1438 (1999)
  • Nishida, K., Yoshida, Y., Itoh, M., Fukada, T., Ohtani, T., Shirogane, T., Atsumi, T., Takahashi-Tezuka, M., Ishihara, K., Hibi, M., and Hirano, T.
    Gab family adapter proteins act downstream of cytokine and growth factor receptors, and T and B cell antigen receptors.
    Blood 93, 1809-1816 (1999)
  • Kiuchi, N., Nakajima, K., Ichiba, M., Fukada, T., Narimatsu, M., Mizuno, K., Hibi, M., and Hirano, T.
    STAT3 is required for the gp130-mediated full activation of the c-myc gene. 
    J. Exp. Med. 189, 63-73 (1999)
  • Fukada, T., Ohtani, T., Yoshida, Y., Shirogane, T., Nishida, K., Nakajima, K., Hibi, M., and Hirano, T.
    STAT3 orchestrates contradictory signals in cytokine-induced G1 to S cell-cycle transition.
    EMBO J. 17, 6670-6677 (1998)
  • Takahashi-Tezuka, M., Yoshida, Y., Fukada, T., Ohtani, T., Yamanaka, Y., Nishida, K., Nakajima, K., Hibi, M., and Hirano, T.
    Gab1 acts as an adaptor molecule linking the cytokine receptor gp130 to ERK Mitogen-Activated Protein Kinase.
    Mol. Cell. Biol. 18, 4109-4117 (1998)
  • Yamanaka, Y., Mizuno, T., Sasai, Y., Kishi, M., Takeda, H., Kim, C-H., Hibi, M., and Hirano, T.
    A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner.
    Genes Dev.12, 2345-2353 (1998)
  • Kim, C-H., Bae, Y-K., Yamanaka, Y., Yamashita, S., Shimizu, T., Fujii, R., Park, H-C., Yeo, S-Y., Huh, T-L., Hibi, M., and Hirano, T.
    Overexpression of neurogenin induces ectopic expression of HuC in zebrafish.
    Neurosci. Lett. 239, 113-116 (1997)
  • Ihara, S., Nakajima, K., Fukada, T., Hibi, M., Nagata, S., Hirano, T., and Fukui, Y.
    Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6.
    EMBO J. 16, 5345-5352 (1997)
  • Hara, T., Murakami, M., Maeda, H., Hibi, M., and Uede T.
    Involvement of a common 10-amino-acid segment in the cytoplasmic region of CD40 but different MAP kinases in different CD40-mediated responses.
    Biochem. Biophys. Res. Comm.233, 187-192. (1997)
  • Lee, IS., Liu, Y., Narazaki, M., Hibi, M., Kishimoto, T., and Taga, T.
    Vav is associated with signal transducing molecules gp130, Grb2, and Erk2, and is tyrosine phosphorylated in response to interleukin-6.
    FEBS Lett. 401, 133-137 (1997)
  • Takahashi-Tezuka, M., Hibi, M., Fujitani, Y., Fukada, T., Yamaguchi, T., and Hirano, T.
    Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK.
    Oncogene 14, 2273-2282 (1997)
  • Qin, S., Minami, Y., Hibi, M., Kurosaki, T., and Yamamura, H.
    Syk-dependent and -independent signaling cascades in B cells elicited by osmotic and oxidative stress.
    J. Biol. Chem. 272, 2098-2103 (1997)
  • Fujitani, Y., Hibi, M., Fukada, T., Takahashi-Tezuka, M., Yoshida, H., Yamaguchi, T., Sugiyama, K., Yamanaka, Y., Nakajima, K., and Hirano, T.
    An alternative pathway for STAT activation that is mediated by direct interaction of JAK and STAT.
    Oncogene 14, 751-761 (1997)
  • Fukada, T., Hibi, M., Yamanaka, Y., Takahashi-Tezuka, M., Fujitani, Y., Yamaguchi, T., Nakajima, K., and Hirano, T.
    Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis.
    Immunity 5, 449-460 (1996)
  • Kallunki, T., Deng, T., Hibi, M., and Karin, M.
    c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions.
    Cell 87, 929-939 (1996)
  • Claret, F-X., Hibi, M., Dhut, S., Toda, T., and Karin, M.
    Jun activation domaind binding proteins: a new group of conserved coactivators that increase the specificity of AP-1 factors.
    Nature 383, 453-457 (1996)
  • Nakajima, K., Yamanaka, Y., Nakae, H., Kojima, H., Kiuchi, N., Ichiba, M., Kitaoka, T., Fukada, T., Hibi, M., and Hirano, T.
    A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells.
    EMBO J. 15, 3651-3658 (1996)
  • Yamanaka, Y., Nakajima, K., Fukada, T., Hibi, M., and Hirano, T.
    Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation.
    EMBO J. 15, 1557-1565 (1996)
  • Mochizuki, N., Hibi, M., Kanai, Y., and Insel, P.A.
    Interaction of the protein nucleobindin with Gai2, as revealed by the yeast two-hybrid system.
    FEBS Letters 373, 155-158 (1995)
  • Smeal, T., Hibi, M., and Karin, M.
    Altering the specificity of sinal transduction cascades: positive regulation of c-Jun trans criptional activity by protein kinase A.
    EMBO J. 13, 6006-6010 (1994)
  • Westwick, J.K., Cox, A.D., Der, C.J., Cobb, M.H., Hibi, M., Karin, M. and Brennerl, D.A.
    Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases.
    Proc. Natl. Acad. Sci. USA.91, 6030-6034 (1994)
  • Su, B., Jacinto, E., Hibi, M., Kallunki, T., Karin, M., and Ben-Neriah, Y.
    JNK is involved in signal integration during costimulation of T lymphocytes.
    Cell 77, 727-736 (1994)
  • Derijard, B., Hibi, M., Wu, I-H., Barrett, T., Su, B., Deng, T., Karin, M., and Davis, R.J.
    JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain.
    Cell 76, 1025-1037 (1994) 
  • Hibi, M., Lin, A., Smeal, T., Minden, A., and Karin, M.
    Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.
    Genes Dev. 7, 2135-2148 (1993)
  • Yawata, H., Yasukawa, K., Natsuka, S., Mirakami, M., Yamasaki, K., Hibi, M., Taga, T., and Kishimoto, T.
    Strucutre- function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6 binding and for IL-6 signal transduction through gp130. 
    EMBO J. 12, 1705-1712 (1993)
  • Murakami, M., Hibi, M., Nakagawa, N., Nakagawa, T., Yasukawa, K., Yamanishi, K., Taga, T., and Kishimoto, T.
    IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase.
    Science 260, 1808-1810 (1993)
  • Falus, A., Taga, T., Hibi, M., Murakami, M., and Kishimoto, T.
    Regulation of IL-6 receptor and gp130 expression on human cell lines of lymphoid and myeloid origin.
    Cytokine 4, 495-499 (1992)
  • Saito, M., Yoshida, K., Hibi, M., Taga, T., and Kishimoto, T.
    Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo.
    J. Immunol. 148, 4066-4071 (1992)
  • Murakami, M., Narazaki, M., Hibi, M., Yawata, H., Yasukawa, K., Hamaguchi, M., Taga, T., and Kishimoto, T.
    Critical cytoplasmic region of the interleukin-6 signal transducer gp130 is conserved in the cytokine receptor family.
    Proc. Natl. Acad. Sci. USA. 88, 11349-11353 (1991)
  • Hibi, M., Murakami, M., Saito, M., Hirano, T., Taga, T., and Kishimoto, T.
    Molecular cloning and expression of an IL-6 signal transducer, gp130.
    Cell63, 1149-1157 (1990)
  • Hirata, Y., Taga, T., Hibi, M., Nakano, N., Hirano, T., and Kishimoto, T.
    Characterization of IL-6 receptor expression by monoclonal and polyclonal antibodies.
    J. Immunol. 143, 2900-2906 (1989)
  • Taga, T., Hibi, M., Hirata, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T., and Kishimoto, T.
    Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130.
    Cell 58, 573-581 (1989)

総説

  • Hibi, M., Matsuda, K., Takeuchi, M., Shimizu, T., and Murakami, Y.
    Evolutionary mechanisms that generate morphology and neural-circuit diversity of the cerebellum.
    Dev. Growth Differ. 59, 228-243 (2017)
  • Hibi, M. and Shimizu, T.
    Deciphering Cerebellar Neural Circuitry Involved in Higher Order Functions Using the Zebrafish Model.
    in: Kondoh, H. and Kuroiwa, A. (Eds.), New Principles in Developmental ProcessesSpringer, pp. 161-184 (2014)
  • Hashimoto, M. and Hibi, M.
    Development and evolution of cerebellar neural circuits.
    Dev. Growth Differ. 54, 373-389 (2012)
  • Hibi, M. and Shimizu, T.
    Development of the cerebellum and cerebellar neural circuits.
    Dev. Neurobiol.72, 282-301 (2012)
  • Shimizu, T. and Hibi, M.
    Formation and patterning of the forebrain and olfactory system by zinc finger genes Fezf1 and Fezf2.
    Dev. Growth Differ. 51, 221-231 (2009)
  • 日比正彦
    分泌シグナル分子による脊腹軸形成機構
    細胞工学 26, 1142-1146(2007)
  • 村岡修、日比正彦
    SizzledによるChordinタンパク質の分解抑制と背腹軸形成の制御
    実験医学 24, 1658-1661(2006)
  • 日比正彦
    前脳形成における転写因子Fez, Fez-likeの役割
    生体の科学 56, 311-318(2005)
  • 日比正彦
    基礎発生生物学の再生医療における役割―胚葉形成・体軸形成― 
    病理と臨床 21, 743-749(2003)
  • Hibi, M., Hirano, T., and Dawid, I.B.
    Organizer formation and function.
    Results Probl. Cell Differ. 40, 48-71 (2002)
  • 日比正彦
    脊椎動物の体軸形成におけるWntシグナルの役割 
    細胞工学 19, 1634-1643(2000)
  • 日比正彦、清水貴史、橋本寿史、柳成林、山中庸次郎、平野俊夫
    脊椎動物初期体軸形成の分子機構 ゼブラフィッシュからの知見 
    蛋白質核酸酵素 45, 2720-2731(2000)
  • Hirano, T., Ishihara, K., and Hibi, M.
    Roles of STAT3 in mediating the cell growth, differentiation, and survivial signals related through the IL-6 family of cytokine receptors. 
    Oncogene 19, 2548-2556 (2000)
  • Ohtani, T., Ishihara, K., Atsumi, T., Yoshida, Y., Nishida, K., Narimatsu, M., Shirogane, T., Hibi, M., and Hirano, T.
    gp130-mediated signalings as therapeutic targets.
    Emerging Therapeutic Targets 4, 459-479 (2000)
  • Hibi, M. and Hirano, T.
    Gab-family adapter molecules in signal transduction of cytokine and growth factor receptors, and T and B cell antigen receptors.
    Leuk. Lymphoma 37, 299-307 (2000)
  • Fukada, T., Yoshida, Y., Nishida, K., Ohtani, T., Shirogane, T., Hibi, M., and Hirano, T.
    Signaling through gp130: toward a general senario of cytokine action.
    Growth Factors 17, 81-91 (1999)
  • Hibi, M. and Hirano, T.
    Signal transduction through cytokine receptors.
    Intern. Rev. Immunol. 17, 75-102 (1998)
  • Hirano, T., Nakajima, K, and Hibi, M.
    Signaling mechanisms through gp130: a model of the cytokine system.
    Cytokine Growth Factor Rev. 8, 241-252 (1997)
  • 日比正彦
    AP-1転写因子とその活性調節機構
    実験医学 15, 541-544 (1997)
  • Hibi, M., Nakajima, K., and Hirano, T.
    IL-6 cytokine family and signal transduction: a model of the cytokine system.
    J. Mol. Med. 74, 1-12 (1996)
  • 日比正彦
    シグナル伝達と転写因子AP-1
    実験医学 11, 105-111 (1993) 
  • Kishimoto, T., Hibi, M., Murakami, M., Narazaki, M., Saito, M., and Taga, T.
    The molecular biology of interleuin 6 and its receptor.
    Ciba Found.Symp. 167, 5-16 (1992)
  • Taga, T., Hibi, M. Murakami, M., Saito, M., Yawata, H., Narazaki, M., Hirata, Y., Sugita, T., Yasukawa, K., Hirano, T., and Kishimoto, T.
    Interleukin-6 receptor and signals.
    Chem. Immunol. 51, 181-204 (1992)
  • Suematsu, S., Hibi, M., Sugita, T., Saito, M., Murakami, M., Matsusaka, T., Matsuda, T., Hirano, T., Taga, T., and Kishimoto, T.
    Interleukin 6 (IL-6) and its receptor (IL-6R) in myeloma, plasmacytoma.
    Curr. Top. Microbiol. Immunol. 166, 13-22 (1990)
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    The immunobiology of interleukin-6 (IL-6) and its receptor.
    In: Advances in Host Defense Mechanisms Vol. 7, Molecular Aspects of Immune Response and Infectious Deiseases,
    edt. by H. Kiyono, E. Jirillo, and C. Desimone, Raven Press, Ltd., New York. p.19-22 (1990)
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    Interleukin 6 and its receptor in the immune response and hematopoiesis.
    Intl. J. Cell Cloning 8, 155-166 (1990)
  • Kishimoto, T., Taga, T., Matsuda, T., Hibi, M., Suematsu, S., Tang, B., Yawata, H., Hirata, Y., Yamasaki, K., and Hirano, T.
    Interleukin-6 and its receptor in immune regulation.
    In: Progress in Immunology,
    edt. by F. Melchers et al., Springer-Verlag Berlin Heidel berg, Vol. 7, 633-640 (1989)
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    Interleukin-6 and its receptor.
    In: Receptor Progress in Cytokine Research. p.265-285 (1989)
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    Structure and expression of interleukin-6 receptor.
    In: The Biology of Interferon System 1988,
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