Publications

Publication list of Masahiko Hibi

Original Articles

  • Motohiro Miyadai, Hiroyuki Takada, Akiko Shiraishi, Tetsuaki Kimura, Ikuko Watakabe, Hikaru Kobayashi, Yusuke Nagao, Kiyoshi Naruse, Shin-ichi Higashijima, Takashi Shimizu, Robert N. Kelsh, Masahiko Hibi, Hisashi Hashimoto.
    A gene regulatory network combining Pax3/7, Sox10 and Mitf generates diverse pigment cell types in medaka and zebrafish. Development. 150(19): dev202114. (2023)
  • Hanako Hagio, Wataru Koyama, Shiori Hosaka, Aysenur Deniz Song, Janchiv Narantsatsral, Koji Matsuda, Takashi Shimizu, Shoko Hososhima, Satoshi P Tsunoda, Hideki Kandori, Masahiko Hibi.
    Optogenetic manipulation of neuronal and cardiomyocyte functions in zebrafish using microbial rhodopsins and adenylyl cyclases. elife. DOI: 10.7554/eLife.83975 (2023)
  • Hanako Hagio, Wataru Koyama, Shiori Hosaka, Aysenur Deniz Song, Janchiv Narantsatsral, Koji Matsuda, Tomohiro Sugihara, Takashi Shimizu, Mitsumasa Koyanagi, Akihisa Terakita, Masahiko Hibi.
    Optogenetic manipulation of Gq- and Gi/o-coupled receptor signaling in neurons and heart muscle cells. elife. DOI: 10.7554/eLife.83974 (2023)
  • Wu D, Arakawa H, Fujita A, Hashimoto H, Hibi M, Naruse K, Kamei Y, Sato C, Kitajima K.
    A point-mutation in the C-domain of CMP-sialic acid synthetase leads to lethality of medaka due to protein insolubility.
    Sci Rep. 11(1):23211. DOI:10.1038/s41598-021-01715-3. (2021).
  • Kim J, Hyun M, Hibi M, You YJ.
    Maintenance of quiescent oocytes by noradrenergic signals.
    Nat Commun. 12(1):6925. DOI:10.1038/s41467-021-26945-x. (2021).
  • Tsunogai Y, Miyadai M, Nagao Y, Sugiwaka K, Kelsh RN, Hibi M, Hashimoto H.
    Contribution of sox9b to pigment cell formation in medaka fish.
    Dev Growth Differ. DOI:10.1111/dgd.12760 (2021).
  • Ikenaga T, Shimomai R, Hagio H, Kimura S, Matsumoto K, Kato DI, Uesugi K, Takeuchi A, Yamamoto N, Hibi M
    Morphological analysis of the cerebellum and its efferent system in a basal actinopterygian fish, Polypterus senegalus.
    J Comp Neurol. DOI:10.1002/cne.25271 (2021).
  • Tsubasa Itoh, Shinsuke Inoue, Xiaoding Sun, Ryo Kusuda, Hibi M, Takashi Shimizu.
    Cfdp1 controls the cell cycle and neural differentiation in the zebrafish cerebellum and retina.
    Developmental Dynamics. DOI:10.1002/dvdy.371 (2021).
  • Wataru Koyama, Ryo Hosomi, Koji Matsuda, Koichi Kawakami, Hibi M, Takashi Shimizu.
    Involvement of Cerebellar Neural Circuits in Active Avoidance Conditioning in Zebrafish.
    eNeuro. 8(3) (2021).
  • Itoh T, Takeuchi M, Sakagami, M, Asakawa K, Sumiyama K, Kawakami K, Shimizu T, Hibi M.
    Gsx2 is required for specification of neurons in the inferior olivary nuclei from Ptf1a-expressing neural progenitors in zebrafish.
    Development. 147, dev190603. doi: 10.1242/dev.190603. (2020).
  • Chang W, Pedroni A, Hohendorf V, Giacomello S, Hibi M, Koster RW, Ampatzis K.
    Functionally distinct Purkinje cell types show temporal precision in encoding locomotion.
    Proc Natl Acad Sci U S A. 117, 17330-17337 (2020).
  • Sugiura M, Tsunoda SP, Hibi M, Kandori H.
    Molecular Properties of New Enzyme Rhodopsins With Phosphodiesterase Activity.
    ACS Omega. 5, 10602-10609 (2020).
  • Verreet T, Weaver CJ, Hino H, Hibi M, Poulain FE.
    Syntaphilin-mediated docking of mitochondria at the growth cone is dispensable for axon elongation in vivo.
    eNeuro. 6, ENEURO.0026-19 (2019).
  • Nimura T, Itoh T, Hanako H, Hayashi T, V Di Donato, Takeuchi M, Itoh T, Inoguchi F, Sato Y, Yamamoto N, Katsuyama Y, F D Bene, Shimizu T, Hibi M.
    Role of Reelin in cell positioning in the cerebellum and the cerebellum-like structure in zebrafish.
    Dev Biol. 455, 393-408 (2019).
  • Dohaku R, Yamaguchi M, Yamamoto N, Shimizu T, Osakada F and Hibi M.
    Tracing of afferent connections in the zebrafish cerebellum using recombinant rabies virus.
    Front Neural Circuits. 13, 30 (2019).
  • Hara Y, Takeuchi M, Kageyama Y, Tatsumi K, Hibi M, Kiyonari H, Kuraku S.
    Madagascar ground gecko genome analysis characterizes asymmetric fates of duplicated genes.
    BMC Biol. 16, 40 (2018).
  • Nagao Y, Takada H, Miyadai M, Adachi T, Seki R, Kamei Y, Hara I, Taniguchi Y, Naruse K, Hibi M, Kelsh RN, Hashimoto H.
    Distinct interactions of Sox5 and Sox10 in fate specification of pigment cells in medaka and zebrafish.
    PLoS Genet. 14, e1007260 (2018).
  • Kidwell CU, Su CY, Hibi M, Moens CB.
    Multiple zebrafish atoh1 genes specify a diversity of neuronal types in the zebrafish cerebellum.
    Dev Biol. 438, 96-107 (2018)
  • Hino H, Nakanishi A, Seki R, Aoki T, Yamaha E, Kawahara A, Shimizu T, Hibi M.
    Roles of maternal wnt8a transcripts in axis formation in zebrafish.
    Dev Biol. 434, 96-107 (2018).
  • Matsuda, K., Yoshida, M., Kawakami, K., Hibi, M. and Shimizu, T.
    Granule cells control recovery from classical conditioned fear responses in the zebrafish cerebellum.
    Sci Rep 7, 11865 (2017)
  • Takeuchi, M., Inoue, C., Goshima, A., Nagao, Y., Shimizu, K., Miyamoto, H., Shimizu, T., Hashimoto, H., Yonemura, S., Kawahara, A., Hirata, Y., Yoshida, M., and Hibi, M.
    Medaka and zebrafish contactin1 mutants as a model for understanding neural circuits for motor coordination.
    Genes Cells 22, 723-741 (2017)
  • Yun, U.J., Sung, J.Y., Park, S.Y., Ye, S.K., Shim, J., Lee, J.S., Hibi, M., Bae, Y.K., and Kim, Y.N.
    OOncogenic role of rab escort protein 1 through EGFR and STAT3 pathway.
    Cell Death Dis. 8, e2621 (2017)
  • Song, K.H., Woo, S.R., Chung, J.Y., Lee, H.J., Oh, S.J., Hong, S.O., Shim, J., Kim, Y.N., Rho, S.B., Hong, S.M., Cho, H., Hibi, M.., Bae, D.J., Kim, S.Y., Kim, M.G., Kim, T.W., and Bae, Y.K.
    REP1 inhibits FOXO3-mediated apoptosis to promote cancer cell survival.
    Cell Death Dis. 8, e2536 (2017)
  • Chiba, A., Watanabe-Takano, H., Terai, K., Fukui, H., Miyazaki, T., Uemura, M., Hashimoto, H., Hibi, M., Fukuhara, S., and Mochizuki, N.
    Biochemical characterization of the medaka (Oryzias latipes) orthologue for mammalian tissue-type transglutaminase (TG2).
    Development 144, 334-344 (2017)
  • Takeuchi, M., Yamaguchi, S., Sakakibara, Y., Hayashi, T., Matsuda, K., Hara, Y., Tanegashima, C., Shimizu, T., Kuraku, S., and Hibi, M.
    Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum.
    J. Comp. Neurol. 525, 1558-1585 (2017)
  • Scalise, K., Shimizu, T., Hibi, M., and Sawtell, NB.
    Responses of cerebellar Purkinje cells during fictive optomotor behavior in larval zebrafish.
    J. Neurophysiol. 116, 2067-2080 (2016)
  • Kim, JD., Park, KE., Ishida, J., Kako, K., Hamada, J., Kani, S., Takeuchi, M., Namiki, K., Fukui, H., Fukuhara, S., Hibi, M., Kobayashi, M., Kanaho, Y., Kasuya, Y., Mochizuki, N., and Fukamizu, A.
    PRMT8 as a phospholipase regulates Purkinje cell dendritic arborization and motor coordination.
    Sci. Adv. 1, e1500615 (2015)
  • Takeuchi, M., Yamaguchi, S., Yonemura, S., Kakiguchi, K., Sato, Y., Higashiyama, T, Shimizu, T., and Hibi, M.
    Type IV Collagen Controls the Axogenesis of Cerebellar Granule Cells by Regulating Basement Membrane Integrity in Zebrafish.
    PLoS Genet. 11, e1005587 (2015)
  • Takeuchi, M., Matsuda, K., Yamaguchi, S., Asakawa, K., Miyasaka, N., Lal, P. Yoshihara, Y., Koga, A., Kawakami, K., Shimizu, T., and Hibi, M.
    Establishment of Gal4 transgenic zebrafish lines for analysis of development of cerebellar neural circuitry.
    Dev. Biol. 397, 1-17 (2015)
  • Nagao, Y., Suzuki, T., Shimizu, A., Kimurata, T., Seki, R., Adachi, T., Inoue, C., Omae, Y., Kamei, Y., Hara, I., Taniguchi, Y., Naruse, K., Wakamatsu, Y., Kelsh, R.N. Hibi, M., and Hashimoto, H.
    Sox5 functions as a fate switch in medaka pigment cell development.
    PLoS Genet. 10, e1004246 (2014)
  • Kwon, H.B., Fukuhara, S., Asakawa, K., Ando, K., Kashiwada, T., Kawakami, K., Hibi, M., Kwon, Y.G., Kim, K.W., Alitalo, K., and Mochizuki, N.
    The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc/Vegfr3 signaling in zebrafish.
    Development 140, 4081-4090 (2013)
  • Yanicostas, C., Barbieri, E., Hibi, M., Brice, A., Stevanin, G., and Soussi-Yaniscostas, N.
    Requirement for zebrafish ataxin-7 in differentiation of photoreceptors and cerebellar neurons.
    PLoS One 7, e50705 (2012)
  • Tran, L.D., Hino, H., Quach, H., Lim, S., Shindo, A., Mimori-Kiyosue, Y., Mione, M., Ueno, N., Winkler, C., Hibi, M., and Sampath, K.
    Dynamic microtubules at the vegetal cortex predict the embryonic axis in zebrafish.
    Development 139, 3644-3652 (2012)
  • Kuscha, V., Frazer, S.L., Dias, T.B., Hibi, M., Becker, T., and Becker, C.G.
    Lesion-induced generation of interneuron cell types in specific dorsoventral domains in the spinal cord of adult zebrafish.
    J. Comp. Neurol. 520, 3604-3616 (2012)
  • Moriyama, Y., Kawanishi, T., Nakamura, R., Tsukahara, T., Sumiyama, K., Suster, M.L., Kawakami, K., Toyada, A., Fujiyama, A., Yasuoka, Y., Nagao, Y. Sawatari, E., Shimizu, A., Wakamatsu, Y., Hibi, M., Taira, M., Okabe, M., Naruse, K., Hashimoto, H., Shimada, A., and Takeda, H.
    The medaka zic1/zic4 mutant provides molecular insights into teleost caudal fin evolution.
    Curr. Biol. 22, 601-607 (2012)
  • Imai, H., Oomiya, Y., Kikkawa, S., Shoji, W., Hibi, M., Terashima, T., and Katsuyama, Y.
    Dynamic changes in the gene expression of zebrafish Reelin receptors during embryogenesis and htaching period.
    Dev. Growth Differ. 54, 53-263 (2012)
  • Takano, A., Zochi, R., Hibi, M., Terashima, T., and Katsuyama, Y.
    Function of strawberry notch family genes in the zebrafish brain develoment.
    Kobe J. Med. Sci. 56, E220-E230 (2011)
  • Tanabe, K., Kani, S., Shimizu, T., Bae, Y.-K., Abe, T., and Hibi, M.
    Atypical PKC regulates primary dendrite specification of cerebellar Purkinje cells by localizing Golgi apparatus.
    J. Neurosci. 30, 16983-16992 (2010)
  • Nagao, Y., Cheng, J., Kamura, K., Seki, R., Maeda, A., Nihei, D., Koshida, S., Wakamatsu, Y., Fujimoto, T., Hibi, M., and Hashimoto, H.
    Dynein axonemal intermediate chain 2 is required for formation of the left-right body axis and kidney in medaka.
    Dev. Biol. 347, 53-61 (2010)
  • Takano, A., Zochi, R., Hibi, M., Terashima, T., and Katsuyama, Y.
    Expression of strawberry notch family genes during zebrafish embryogenesis.
    Dev. Dyn. 239, 1789-1796 (2010)
  • Kani, S., Bae, Y.-K., Shimizu, T., Tanabe, K., Satou, C., Parsons, M.J. Scott, E., Higashijima, S.-I., and Hibi, M.
    Proneural gene-linked neurogenesis in zebrafish cerebellum.
    Dev. Biol. 343, 1-17 (2010)
  • Shimizu, T., Nakazawa, M., Kani, S., Bae, Y.-K., Shimizu, T., Kageyama, R., and Hibi, M.
    Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in forebrain.
    Development 137, 1875-1885 (2010)
  • Nojima, H., Rothhämel, S., Shimizu, T., Kim, C.H., Yonemura, S., Marlow, F.L., and Hibi, M.
    Syntabulin, a motor protein linker, controls dorsal determination.
    Development 137, 923-933 (2010)
  • Bae, Y.-K., Kani, S., Shimizu, T., Tanabe, K., Nojima, H., Kimura, Y., Higashijima, S.-I., and Hibi, M.
    Anatomy of zebrafish cerebellum and screen for mutations affecting its development.
    Dev. Biol. 330, 406-426 (2009)
  • Kim, H., Kim, S., Chung, A.Y., Bae, Y.K., Hibi, M., Lim, C.S., and Park, H.C.
    Notch-regulated perineurium development from zebrafish spinal cord.
    Neurosci. Lett. 448, 240-244 (2008)
  • Asakawa, K., Suster, M. L., Mizusawa, K., Nagayoshi, S., Kotani, T., Urasaki, A., Kishimoto, Y., Hibi, M., and Kawakami, K.
    Genetic dissection of neural circuits by Tol2 transposon-mediated Gal4 gene and enhancer trapping in zebrafish.
    Proc. Natl. Acad. Sci. USA. 105, 1255-1260 (2008)
  • Katsuyama, Y., Oomiya, Y., Dekimoto, H., Motooka, E., Takano, A., Kikkawa, S., Hibi, M., and Terashima, T.
    Expression of zebrafish ROR alpha gene in cerebellar-like structures.
    Dev. Dyn. 236, 2694-2701 (2007)
  • Nikaido, M., Doi, K., Shimizu, T., Hibi, M., Kikuchi, Y., and Yamasu, K.
    Initial specification of the epibranchial placode in zebrafish embryos depends on the fibroblast growth factor signal.
    Dev. Dyn. 236, 564-571 (2007)
  • Komuta, Y., Hibi, M., Arai, T., Nakamura, S., and Kawano, H.
    Defects in reciprocal projects between the thalamus and cerebral cortex in the early development of Fezl-deficient mice.
    J. Comp. Neurol. 503, 454-465 (2007)
  • Shimizu, T., Bae, Y.-K., and Hibi, M.
    Cdx-Hox code controls competence for responding to Fgfs and retinoic acid in zebrafish neural tissue.
    Development 133, 4709-4719 (2006)
  • Hirata, T., Nakazawa, M., Muraoka, O., Nakayama, R., Suda, Y., and Hibi, M.
    Zinc-finger genes Fez and Fez-like function in the establishment of diencephalon subdivisions.
    Development 133, 3993-4004 (2006)
  • Hirata, T., Nakazawa, M., Yoshihara, S., Miyachi, H., Kitamura, K., Yoshihara, Y., and Hibi, M.
    Zinc-finger gene Fez in the olfactory neurons regulates development of the olfactory bulb non-cell-autonomously.
    Development 133, 1433-1443 (2006)
  • Muraoka, O., Shimizu, T., Yabe, T., Nojima, H., Bae, Y-K., Hashimoto, H., and Hibi, M.
    Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein.
    Nat. Cell Biol. 8, 329-340 (2006)
  • Molyneaux, B.J., Arlotta, P., Hirata, T., Hibi, M., and Macklis J.D.
    Fezl is required for the birth and specification of corticospinal motor neurons.
    Neuron 47, 817-831 (2005)
  • Shimizu, T., Yabe, T., Muraoka, O., Yonemura, S., Aramaki, S., Hatta, K., Bae, Y.-K., Nojima, H., and Hibi, M.
    E-cadherin is required for gastrulation cell movements in zebrafish.
    Mech. Dev. 122, 747-763 (2005)
  • Bae, Y-K., Shimizu, T., and Hibi, M.
    Patterning of proneuronal and inter-proneuronal domains by hairy- and enhancer of split-related genes in zebrafish neuroectoderm.
    Development 132, 1375-1385 (2005)
  • Shimizu, T., Bae, Y.-K., Muraoka, O., and Hibi, M.
    Interaction of Wnt and caudal-related genes in zebrafish posterior body formation.
    Dev. Biol. 279, 125-141 (2005)
  • Yamamoto, A., Nagano, T., Takehara, S., Hibi, M., and Aizawa, S.
    Shisa promotes head formation through the inhibition of receptor maturation for the caudalizing factors, Wnt and FGF.
    Cell 120, 223-235 (2005)
  • Nojima, H., Shimizu, T. , Kim, C.-H., Yabe, T., Bae, Y.-K., Muraoka, O., Hirata, T., Chitnis, A., Hirano, T., and Hibi, M.
    Genetic evidence for involvement of maternally derived Wnt canonical pathway in dorsal determination in zebrafish.
    Mech. Dev. 121, 371-386 (2004)
  • Hirata, T., Suda, Y., Nakao, K., Narimatsu, M., Hirano, T., and Hibi, M.
    The zinc finger gene fez-like functions in the formation of subplate neurons and thalamocortical axons.
    Dev. Dyn. 230, 546-556 (2004)
  • Hashimoto, H., Rebagliati, M., Ahmad, N., Muraoka, O., Kurokawa, T., Hibi, M.* and Suzuki, T.*
    The Cerberus/Dan-family protein Charon is a negative regulator of Nodal signaling during left-right patterning in zebrafish.
    Development 131, 1741-1753 (2004)*corresponding authors.
  • Bae, Y.-K., Shimizu, T., Muraoka, O., Yabe, T., Hirata, T., Nojima, H., Hirano, T., and Hibi, M.
    Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish.
    Gene Expr. Patterns 4, 481-486 (2004)
  • Yabe, T., Shimizu, T., Muraoka, O., Bae, Y.-K., Hirata, T., Nojima, H., Kawakami, A., Hirano, T., and Hibi, M.
    Ogon/Secreted Frizzled functions as a negative feedback regulator of BMP signaling.
    Development 130, 2705-2716 (2003)
  • Bae, Y.-K., Shimizu, T., Yabe, T., Kim, C.-H., Hirata, T., Nojima, H., Muraoka, O., Hirano, T., and Hibi, M.
    A homeobox gene, pnx, is involved in the formation of posterior neurons in zebrafish.
    Development 130, 1853-1865 (2003)
  • Yamasaki, S., Nishida, K., Yoshida, Y., Itoh, M., Hibi, M., and Hirano, T.
    Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2.
    Oncogene 22, 1546-1556 (2003)
  • Levkowitz, G., Zeller, J., Sirotkin, H.I., French, D., Schilbach, S., Hashimoto, H., Hibi, M., Talbot, W.S., and Rosenthal, A.
    Zinc finger protein too few controls the development of monoaminergic neurons.
    Nat. Neurosci.6, 28-33 (2003)
  • Shimizu, T., Yamanaka, Y., Nojima, H., Yabe, T., Hibi, M., and Hirano, T.
    A novel repressor-type homeobox gene, ved, is involved in dharma/bozozok-mediated dorsal organizer formation in zebrafish.
    Mech. Dev. 118, 125-138 (2002)
  • Itoh, S., Itoh, M., Nishida, K., Yamasaki, S., Yoshida, Y., Narimatsu, M., Park, J.P., Hibi, M., Ishihara, K., and Hirano, T.
    Adapter molecule Grb2-associated binder 1 is specifically expressed in marginal zone B cells and negatively regulates thymus-independent antigen-2 responses.
    J. Immunol. 168, 5110-5116 (2002)
  • Nishida, K., Wang, L., Mori, E., Park, S-J., Narimatsu, M., Itoh, S., Yamasaki, S., Fujishima, M., Ishihara, K., Hibi, M., Kitamura, Y., and Hirano, T.
    Requirement of Gab2 for mast cell development and Kitl/c-Kit signaling.
    Blood 99,1866-1869 (2002)
  • Yamada, K., Nishida, K., Hibi, M., Hirano, T., and Matsuda, Y.
    Comparative FISH mapping of Gab1 and Gab2 genes in human, mouse, and rat.
    Cytogenet Cell Genet. 94, 39-42 (2001)
  • Yamasaki, S., Nishida, K., Hibi, M., Sakuma, M., Shiina, R., Takeuchi, A., Ohnishi, H., Hirano, T., and Saito, T.
    Docking protein Gab2 is phosphorylated by ZAP70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules.
    J. Biol. Chem. 276, 45175-45183 (2001)
  • Narimatsu, M., Maeda, H., Itoh, S., Atsumi, T., Ohtani, T., Nishida, K., Itoh, M., Kamimura, D., Park, SJ., Mizuno, K., Miyazaki, Ji., Hibi, M., Ishihara, K., Nakajima, K., and Hirano, T.
    Tissue-specific autoregulation of the stat3 gene and its role in interleukin-6-induced survival signals in T cells.
    Mol Cell Biol. 21, 6615-6625 (2001)
  • Kojima, H., Shinagawa, A., Shimizu, S., Kanada, H., Hibi, M., Hirano, T., and Nagasawa, T.
    Role of phosphatidylinositol-3 kinase and its association with Gab1 in thrombopoietin-mediated up-regulation of platelet function.
    Exp Hematol. 29, 616-622 (2001)
  • Mizuno, K., Shirogane, T., Shinohara, A., Iwamatsu, A., Hibi, M., and Hirano, T.
    Regulation of Pim-1 by Hsp90.
    Biochem Biophys Res Commun. 281, 663-669 (2001)
  • Ryu, S-L., Fujii, R., Yamanaka, Y., Shimizu, T., Yabe, T., Hirata, T., Hibi, M., and Hirano, T.
    Regulation of dharma/bozozok by the Wnt pathway.
    Dev. Biol. 231, 397-409 (2001)
  • Muraoka, O., Ichikawa, H., Shi, H., Okamura, S., Taira, E., Higuchi, H., Hirano, T., Hibi, M., and Miki, N.
    Kheper, a novel ZFH/dEF1 family, regulates the development of the neuroectoderm of zebrafish (Danio rerio).
    Dev. Biol. 228, 29-40 (2000)
  • Park, H-C., Kim, C-H., Bae, Y-K., Yeo, S-Y., Kim, S-H., Hong, S-K., Shin, J., Hibi, M., Hirano, T., Miki, N., Chitnis, A.B., and Huh, T-L.
    Analysis of upstream elements in the HuC promoter leads to the establishment of transgenic zebrafish with fluorescent neurons.
    Dev. Biol. 227, 279-293 (2000)
  • Fujii, R., Yamashita, S., Hibi, M., and Hirano, T.
    Asymmetric p38 activation in zebrafish; its possible role in symmetric and synchrnous cleavage.
    J. Cell. Biol. 150, 1335-1347 (2000)
  • Hashimoto H., Yabe, T., Hirata, T., Shimizu, T., Bae, Y.-K., Yamanaka, Y., Hirano, T., and Hibi, M.
    Expression of the zinc finger gene fez-like in zebrafish forebrain.
    Mech. Dev. 97, 191-195 (2000)
  • Hirata, T., Yamanaka, Y., Ryu, S.-L., Shimizu, T., Yabe, T., Hibi, M., and Hirano, T.
    Novel mix-family homeobox genes in zebrafish and their differential regulation.
    Biochem. Biophys. Res. Commun. 271, 603-609 (2000)
  • Itoh, M., Yoshida, Y., Nishida, K., Narimatsu, M., Hibi, M., and Hirano, T.
    A role of Gab1 for heart, placenta, and skin development, and growth factors- and cytokines-induced ERK MAP kinase activation.
    Mol. Cell. Biol. 20, 3695-3704 (2000)
  • Daino, H., Matsumura, I., Takeda, K., Oajima, J., Tanaka, H., Ueda, S., Shibayama, H., Ikeda, H., Hibi, M., Hirano, T., and Kanakura, Y.
    Induction of apoptosis by extracellular ubiquitin in human hematopoietic cells: possible involvement of STAT3 degradation by proteasome pathway in interleuikin 6-dependent hematopoietic cells. Blood 95, 2577-2585 (2000)
  • Shimizu, T., Yamanaka, Y., Ryu, S-L., Hashimoto, H., Yabe, T., Hirata, T., Bae, Y-K., Hibi, M., and Hirano, T.
    Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish.
    Mech. Dev. 91, 293-303 (2000)
  • Ohtani, T., Ishihara, K., Atsumi, T., Nishida, K., Kaneko, Y., Miyata, T., Itoh, S., Narimatsu, M., Maeda, H., Fukada, T., Itoh, M., Okano, H., Hibi, M., and Hirano, T.
    Dissection of signaling cascades through gp130 in vivo: Reciprocal roles for STAT3- and SHP2-mediated signals in immune responses.
    Immunity12, 95-105 (2000)
  • Hashimoto, H., Itoh, M., Yamanaka, Y., Yamashita, S., Shimizu, T., Solnica-Krezel, L., Hibi, M., and Hirano, T.
    Zebrafish Dkk1 functions in Forebrain Specification and Axial Mesendoderm Formation.
    Dev. Biol. 217, 138-152 (2000)
  • Shirogane, T., Fukada, T., Muller, J.M.M., Shima, D.T., Hibi, M., and Hirano, T.
    Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and anti-apoptosis. Immunity 11, 709-719 (1999)
  • Ito, M., Yoshioka, K., Akechi, M., Yamashita, S., Takamatsu, N., Sugiyama, K., Hibi, M., Nakabeppu, Y., Shiba, T., and Yamamoto, K-i.
    JSAP1, a novel JNK-binding protein that functions as a scaffolding factor in the JNK signaling pathway.
    Mol. Cell. Biol. 19, 7539-7548 (1999)
  • Nakayama, K., Hara, T., Hibi, M., Hirano, T., and Miyajima, A.
    A novel oncostatin M-inducible gene OIG37 forms a gene family with MyD118 and GADD45 and negatively regulates cell growth.
    J. Biol. Chem. 274, 24766-24772 (1999)
  • Wickrema, A., Uddin, S., Sharma, A., Chen, F., Alsayed, Y., Ahmad, S., Sawyer, S.T., Krystal, G., Yi, T., Nishada, K., Hibi, M., Hirano, T., and Platanias. L.C.
    Engagement of gab1 and gab2 in erythropoietin signaling.
    J. Biol. Chem. 274, 24469-24474 (1999)
  • Fekany, K., Yamanaka, Y., Leung, T., Sirotkin, H. I., Topczewski, J., Gates, M. A., Hibi, M., Renucci, A., Stemple, D., Radbill, A., Schier, A. F., Driever, W., Hirano, T., Talbot, W. S., and Solnica-Krezel, L.
    The zebrafish bozozok locus encodes Dharma, a hemoedomain protein essential for induction of gastrula organizer and dorsoanterior embryonic structures.
    Development 126, 1427-1438 (1999)
  • Nishida, K., Yoshida, Y., Itoh, M., Fukada, T., Ohtani, T., Shirogane, T., Atsumi, T., Takahashi-Tezuka, M., Ishihara, K., Hibi, M., and Hirano, T.
    Gab family adapter proteins act downstream of cytokine and growth factor receptors, and T and B cell antigen receptors.
    Blood 93, 1809-1816 (1999)
  • Kiuchi, N., Nakajima, K., Ichiba, M., Fukada, T., Narimatsu, M., Mizuno, K., Hibi, M., and Hirano, T.
    STAT3 is required for the gp130-mediated full activation of the c-myc gene. 
    J. Exp. Med. 189, 63-73 (1999)
  • Fukada, T., Ohtani, T., Yoshida, Y., Shirogane, T., Nishida, K., Nakajima, K., Hibi, M., and Hirano, T.
    STAT3 orchestrates contradictory signals in cytokine-induced G1 to S cell-cycle transition.
    EMBO J. 17, 6670-6677 (1998)
  • Takahashi-Tezuka, M., Yoshida, Y., Fukada, T., Ohtani, T., Yamanaka, Y., Nishida, K., Nakajima, K., Hibi, M., and Hirano, T.
    Gab1 acts as an adaptor molecule linking the cytokine receptor gp130 to ERK Mitogen-Activated Protein Kinase.
    Mol. Cell. Biol. 18, 4109-4117 (1998)
  • Yamanaka, Y., Mizuno, T., Sasai, Y., Kishi, M., Takeda, H., Kim, C-H., Hibi, M., and Hirano, T.
    A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner.
    Genes Dev.12, 2345-2353 (1998)
  • Kim, C-H., Bae, Y-K., Yamanaka, Y., Yamashita, S., Shimizu, T., Fujii, R., Park, H-C., Yeo, S-Y., Huh, T-L., Hibi, M., and Hirano, T.
    Overexpression of neurogenin induces ectopic expression of HuC in zebrafish.
    Neurosci. Lett. 239, 113-116 (1997)
  • Ihara, S., Nakajima, K., Fukada, T., Hibi, M., Nagata, S., Hirano, T., and Fukui, Y.
    Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6.
    EMBO J. 16, 5345-5352 (1997)
  • Hara, T., Murakami, M., Maeda, H., Hibi, M., and Uede T.
    Involvement of a common 10-amino-acid segment in the cytoplasmic region of CD40 but different MAP kinases in different CD40-mediated responses.
    Biochem. Biophys. Res. Comm.233, 187-192. (1997)
  • Lee, IS., Liu, Y., Narazaki, M., Hibi, M., Kishimoto, T., and Taga, T.
    Vav is associated with signal transducing molecules gp130, Grb2, and Erk2, and is tyrosine phosphorylated in response to interleukin-6.
    FEBS Lett. 401, 133-137 (1997)
  • Takahashi-Tezuka, M., Hibi, M., Fujitani, Y., Fukada, T., Yamaguchi, T., and Hirano, T.
    Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK.
    Oncogene 14, 2273-2282 (1997)
  • Qin, S., Minami, Y., Hibi, M., Kurosaki, T., and Yamamura, H.
    Syk-dependent and -independent signaling cascades in B cells elicited by osmotic and oxidative stress.
    J. Biol. Chem. 272, 2098-2103 (1997)
  • Fujitani, Y., Hibi, M., Fukada, T., Takahashi-Tezuka, M., Yoshida, H., Yamaguchi, T., Sugiyama, K., Yamanaka, Y., Nakajima, K., and Hirano, T.
    An alternative pathway for STAT activation that is mediated by direct interaction of JAK and STAT.
    Oncogene 14, 751-761 (1997)
  • Fukada, T., Hibi, M., Yamanaka, Y., Takahashi-Tezuka, M., Fujitani, Y., Yamaguchi, T., Nakajima, K., and Hirano, T.
    Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis.
    Immunity 5, 449-460 (1996)
  • Kallunki, T., Deng, T., Hibi, M., and Karin, M.
    c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions.
    Cell 87, 929-939 (1996)
  • Claret, F-X., Hibi, M., Dhut, S., Toda, T., and Karin, M.
    Jun activation domaind binding proteins: a new group of conserved coactivators that increase the specificity of AP-1 factors.
    Nature 383, 453-457 (1996)
  • Nakajima, K., Yamanaka, Y., Nakae, H., Kojima, H., Kiuchi, N., Ichiba, M., Kitaoka, T., Fukada, T., Hibi, M., and Hirano, T.
    A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells.
    EMBO J. 15, 3651-3658 (1996)
  • Yamanaka, Y., Nakajima, K., Fukada, T., Hibi, M., and Hirano, T.
    Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation.
    EMBO J. 15, 1557-1565 (1996)
  • Mochizuki, N., Hibi, M., Kanai, Y., and Insel, P.A.
    Interaction of the protein nucleobindin with Gai2, as revealed by the yeast two-hybrid system.
    FEBS Letters 373, 155-158 (1995)
  • Smeal, T., Hibi, M., and Karin, M.
    Altering the specificity of sinal transduction cascades: positive regulation of c-Jun trans criptional activity by protein kinase A.
    EMBO J. 13, 6006-6010 (1994)
  • Westwick, J.K., Cox, A.D., Der, C.J., Cobb, M.H., Hibi, M., Karin, M. and Brennerl, D.A.
    Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases.
    Proc. Natl. Acad. Sci. USA.91, 6030-6034 (1994)
  • Su, B., Jacinto, E., Hibi, M., Kallunki, T., Karin, M., and Ben-Neriah, Y.
    JNK is involved in signal integration during costimulation of T lymphocytes.
    Cell 77, 727-736 (1994)
  • Derijard, B., Hibi, M., Wu, I-H., Barrett, T., Su, B., Deng, T., Karin, M., and Davis, R.J.
    JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain.
    Cell 76, 1025-1037 (1994) 
  • Hibi, M., Lin, A., Smeal, T., Minden, A., and Karin, M.
    Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.
    Genes Dev. 7, 2135-2148 (1993)
  • Yawata, H., Yasukawa, K., Natsuka, S., Mirakami, M., Yamasaki, K., Hibi, M., Taga, T., and Kishimoto, T.
    Strucutre- function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6 binding and for IL-6 signal transduction through gp130. 
    EMBO J. 12, 1705-1712 (1993)
  • Murakami, M., Hibi, M., Nakagawa, N., Nakagawa, T., Yasukawa, K., Yamanishi, K., Taga, T., and Kishimoto, T.
    IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase.
    Science 260, 1808-1810 (1993)
  • Falus, A., Taga, T., Hibi, M., Murakami, M., and Kishimoto, T.
    Regulation of IL-6 receptor and gp130 expression on human cell lines of lymphoid and myeloid origin.
    Cytokine 4, 495-499 (1992)
  • Saito, M., Yoshida, K., Hibi, M., Taga, T., and Kishimoto, T.
    Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo.
    J. Immunol. 148, 4066-4071 (1992)
  • Murakami, M., Narazaki, M., Hibi, M., Yawata, H., Yasukawa, K., Hamaguchi, M., Taga, T., and Kishimoto, T.
    Critical cytoplasmic region of the interleukin-6 signal transducer gp130 is conserved in the cytokine receptor family.
    Proc. Natl. Acad. Sci. USA. 88, 11349-11353 (1991)
  • Hibi, M., Murakami, M., Saito, M., Hirano, T., Taga, T., and Kishimoto, T.
    Molecular cloning and expression of an IL-6 signal transducer, gp130.
    Cell63, 1149-1157 (1990)
  • Hirata, Y., Taga, T., Hibi, M., Nakano, N., Hirano, T., and Kishimoto, T.
    Characterization of IL-6 receptor expression by monoclonal and polyclonal antibodies.
    J. Immunol. 143, 2900-2906 (1989)
  • Taga, T., Hibi, M., Hirata, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T., and Kishimoto, T.
    Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130.
    Cell 58, 573-581 (1989)

Reviews

  • Hibi, M., Matsuda, K., Takeuchi, M., Shimizu, T., and Murakami, Y.
    Evolutionary mechanisms that generate morphology and neural-circuit diversity of the cerebellum.
    Dev. Growth Differ. 59, 228-243 (2017)
  • Hibi, M. and Shimizu, T.
    Deciphering Cerebellar Neural Circuitry Involved in Higher Order Functions Using the Zebrafish Model.
    in: Kondoh, H. and Kuroiwa, A. (Eds.), New Principles in Developmental ProcessesSpringer, pp. 161-184 (2014)
  • Hashimoto, M. and Hibi, M.
    Development and evolution of cerebellar neural circuits.
    Dev. Growth Differ. 54, 373-389 (2012)
  • Hibi, M. and Shimizu, T.
    Development of the cerebellum and cerebellar neural circuits.
    Dev. Neurobiol.72, 282-301 (2012)
  • Shimizu, T. and Hibi, M.
    Formation and patterning of the forebrain and olfactory system by zinc finger genes Fezf1 and Fezf2.
    Dev. Growth Differ. 51, 221-231 (2009)
  • 日比正彦
    分泌シグナル分子による脊腹軸形成機構
    細胞工学 26, 1142-1146(2007)
  • 村岡修、日比正彦
    SizzledによるChordinタンパク質の分解抑制と背腹軸形成の制御
    実験医学 24, 1658-1661(2006)
  • 日比正彦
    前脳形成における転写因子Fez, Fez-likeの役割
    生体の科学 56, 311-318(2005)
  • 日比正彦
    基礎発生生物学の再生医療における役割―胚葉形成・体軸形成― 
    病理と臨床 21, 743-749(2003)
  • Hibi, M., Hirano, T., and Dawid, I.B.
    Organizer formation and function.
    Results Probl. Cell Differ. 40, 48-71 (2002)
  • 日比正彦
    脊椎動物の体軸形成におけるWntシグナルの役割 
    細胞工学 19, 1634-1643(2000)
  • 日比正彦、清水貴史、橋本寿史、柳成林、山中庸次郎、平野俊夫
    脊椎動物初期体軸形成の分子機構 ゼブラフィッシュからの知見 
    蛋白質核酸酵素 45, 2720-2731(2000)
  • Hirano, T., Ishihara, K., and Hibi, M.
    Roles of STAT3 in mediating the cell growth, differentiation, and survivial signals related through the IL-6 family of cytokine receptors. 
    Oncogene 19, 2548-2556 (2000)
  • Ohtani, T., Ishihara, K., Atsumi, T., Yoshida, Y., Nishida, K., Narimatsu, M., Shirogane, T., Hibi, M., and Hirano, T.
    gp130-mediated signalings as therapeutic targets.
    Emerging Therapeutic Targets 4, 459-479 (2000)
  • Hibi, M. and Hirano, T.
    Gab-family adapter molecules in signal transduction of cytokine and growth factor receptors, and T and B cell antigen receptors.
    Leuk. Lymphoma 37, 299-307 (2000)
  • Fukada, T., Yoshida, Y., Nishida, K., Ohtani, T., Shirogane, T., Hibi, M., and Hirano, T.
    Signaling through gp130: toward a general senario of cytokine action.
    Growth Factors 17, 81-91 (1999)
  • Hibi, M. and Hirano, T.
    Signal transduction through cytokine receptors.
    Intern. Rev. Immunol. 17, 75-102 (1998)
  • Hirano, T., Nakajima, K, and Hibi, M.
    Signaling mechanisms through gp130: a model of the cytokine system.
    Cytokine Growth Factor Rev. 8, 241-252 (1997)
  • 日比正彦
    AP-1転写因子とその活性調節機構
    実験医学 15, 541-544 (1997)
  • Hibi, M., Nakajima, K., and Hirano, T.
    IL-6 cytokine family and signal transduction: a model of the cytokine system.
    J. Mol. Med. 74, 1-12 (1996)
  • 日比正彦
    シグナル伝達と転写因子AP-1
    実験医学 11, 105-111 (1993) 
  • Kishimoto, T., Hibi, M., Murakami, M., Narazaki, M., Saito, M., and Taga, T.
    The molecular biology of interleuin 6 and its receptor.
    Ciba Found.Symp. 167, 5-16 (1992)
  • Taga, T., Hibi, M. Murakami, M., Saito, M., Yawata, H., Narazaki, M., Hirata, Y., Sugita, T., Yasukawa, K., Hirano, T., and Kishimoto, T.
    Interleukin-6 receptor and signals.
    Chem. Immunol. 51, 181-204 (1992)
  • Suematsu, S., Hibi, M., Sugita, T., Saito, M., Murakami, M., Matsusaka, T., Matsuda, T., Hirano, T., Taga, T., and Kishimoto, T.
    Interleukin 6 (IL-6) and its receptor (IL-6R) in myeloma, plasmacytoma.
    Curr. Top. Microbiol. Immunol. 166, 13-22 (1990)
  • Kishimoto, T., Hirano, T., Taga, T., Matsuda, T., Suematsu, S., Hibi, M., Yamasaki, K., Yasukawa, K., and Hirata, Y.
    The immunobiology of interleukin-6 (IL-6) and its receptor.
    In: Advances in Host Defense Mechanisms Vol. 7, Molecular Aspects of Immune Response and Infectious Deiseases,
    edt. by H. Kiyono, E. Jirillo, and C. Desimone, Raven Press, Ltd., New York. p.19-22 (1990)
  • Hirano, T. Taga, T., Matsuda, T., Hibi, M., Suematsu, S., Tang, B., Murakami, M., and Kishimoto, T.
    Interleukin 6 and its receptor in the immune response and hematopoiesis.
    Intl. J. Cell Cloning 8, 155-166 (1990)
  • Kishimoto, T., Taga, T., Matsuda, T., Hibi, M., Suematsu, S., Tang, B., Yawata, H., Hirata, Y., Yamasaki, K., and Hirano, T.
    Interleukin-6 and its receptor in immune regulation.
    In: Progress in Immunology,
    edt. by F. Melchers et al., Springer-Verlag Berlin Heidel berg, Vol. 7, 633-640 (1989)
  • Hirano, T., Taga, T., Yamasaki, K., Matsuda, T., Suematsu, S., Tang, B., Hirata, Y., Yawata, H., Hibi, M., Natsuka, S., Akira, S., Yoshizaki, K., Kawano, K., Yamamura, K., and Kishimoto, T.
    Interleukin-6 and its receptor.
    In: Receptor Progress in Cytokine Research. p.265-285 (1989)
  • Hirano, T., Yamasaki, K., Taga, T., Hirata, Y., Yawata, H., Hibi, M., Natsuka, S., and Kishimoto, T.
    Structure and expression of interleukin-6 receptor.
    In: The Biology of Interferon System 1988,
    edt. by Y. Kawade and S. Kobayashi,. p.143-147 (1989)

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