研究業績
学術論文(Original Paper)
2022年
- Rina Hatanaka, Erino Araki, Masaya Hane, Shiori Go, Wu Di, Ken Kitajima, Chihiro Sato (2022) The α2,8-sialyltransferase 6 (St8sia6) localizes in the ER and enhances the anchorage-independent cell growth in cancer. Biochemical and Biophysical Research Communications. in press doi: https://doi.org/10.1016/j.bbrc.2022.03.146
- Shiori Go, Chihiro Sato, Masaya Hane, Shinji Go, and Ken Kitajima (2022) Implication of N-glycolylneuraminic acid in regulation of cell adhesiveness of C2C12 myoblast cells during differentiation into myotube cells Glycoconjugate Journal. in press
2021年
- Di Wu, Hiromu Arakawa, Akiko Fujita, Hisashi Hashimoto, Masahiko Hibi, Kiyoshi Naruse, Yasuhiro Kamei, Chihiro Sato, Ken Kitajima. (2021) A point-mutation in the C-domain of CMP-sialic acid synthetase leads to lethality of medaka due to protein insolubility. Scientific Reports. in press
- Kawanishi K, Saha S, Diaz S, Vaill M, Sasmal A, Siddiqui SS, Choudhury BP, Sharma K, Chen X, Schoenhofen IC, Sato C, Kitajima K, Freeze HH, Münster-Kühnel A, Varki A. (2021) Evolutionary conservation of human ketodeoxynonulosonic acid production is independent of sialoglycan biosynthesis. J Clin Invest. 131(5):e137681. doi: 10.1172/JCI137681
- Saha S, Coady A, Sasmal A, Kawanishi K, Choudhury B, Yu H, Sorensen RU, Inostroza J, Schoenhofen IC, Chen X, Münster-Kühnel A, Sato C, Kitajima K, Ram S, Nizet V, Varki A. (2021) Exploring the Impact of Ketodeoxynonulosonic Acid in Host-Pathogen Interactions Using Uptake and Surface Display by Nontypeable Haemophilus influenzae. mBio. 12(1):e03226-20. doi: 10.1128/mBio.03226-20.
- Atsushi Yoshimura, Yuki Asahina, Lan-Yi Chang, Takashi Angata, Hiroshi Tanaka, Ken Kitajima, Chihiro Sato. (2021) Identification and functional characterization of a Siglec-7 counter-receptor on K562 cells. J. Biol. Chem. 296:100477. doi: 10.1016/j.jbc.2021.100477
- Hayakawa T, Terahara M, Fujito NT, Matsunaga T, Teshima KM, Hane M, Kitajima K, Sato C, Takahata N, Satta Y. (2021) Lower promoter activity of the ST8SIA2 gene has been favored in evolving human collective brains. PLoS One. 16(12):e0259897. doi: 10.1371/journal.pone.0259897.
2020年
- Atsushi Yoshimura, Rina Hatanaka, Hiroshi Tanaka, Ken Kitajima, and Chihiro Sato (2020) The conserved arginine residue in all Siglecs is essential for Siglec-7 binding to sialic acid. Biochemical and Biophysical Research Communications. 534, 1069-1075 (doi: 10.1016/j.bbrc.2020.10.023)
- Yi Yang, Ryo Murai, Yuka Takahashi, Airi Mori, Masaya Hane, Ken Kitajima, Chihiro Sato. (2020) Comparative studies of polysialic acids derived from five different vertebrate brains. International Journal of Molecular Sciences. 21(22): 8593 (doi.org/10.3390/ijms21228593)
- Yamakawa, N, Yasuda, Y, Yoshimura, A, Goshima, A, Crocker, P. R, Vergoten, G, Nishiura, Y, Takahashi, T, Hanashima, S, Matsumoto, K, Yamaguchi, Y, Tanaka, H, Kitajima, K, Sato, C. (2020) Discovery of a new sialic acid binding region that regulates Siglec-7. Scientific Reports. 10(1):8647 (doi: 10.1038/s41598-020-64887-4)
- Iwaki Y, Matsunaga E, Takegawa K, Sato C, Kitajima K. (2020) Identification and characterization of a novel, versatile sialidase from a Sphingobacterium that can hydrolyze the glycosides of any sialic acid species at neutral pH. Biochem Biophys Res Commun. 523(2), 487-492 (doi: 10.1016/j.bbrc.2019.12.079).
- Jun Yamada, Chihiro Sato, Kohtarou Konno, Masahiko Watanabe and Shozo Jinno. (2020) PSA-NCAM colocalized with cholecystokinin-expressing cells in the hippocampus is involved in mediating antidepressant efficacy. Journal of Neuroscience. 40(4), 825-842 (doi: 10.1523/JNEUROSCI.1779-19.2019).
- Kitajima K, Yamakawa N, Sato C, Guerardel Y. (2020) Systems glycomics of adult zebrafish (ゼブラフィッシュの全組織グライコミクス). Journal of Japanese Biochemical Society 92(3): 349-359 (doi:10.14952/SEIKAGAKU.2020.920349)
- Airi Mori, Yi Yang, Yuka Takahashi, Masaya Hane, Ken Kitajima, Chihiro Sato. (2020) Combinational Analyses with Multiple Methods Reveal the Existence of Several Forms of Polysialylated Neural Cell Adhesion Molecule in Mouse Developing Brains. Int J Mol Sci. 16;21(16):E5892. (doi: 10.3390/ijms21165892)
- Chihiro Sato, Ken Kitajima (2020) Polysialylation and disease. Mol Aspects Med. Online ahead of print (doi: 10.1016/j.mam.2020.100892)
- Nursah Ertunc , Chihiro Sato & Ken Kitajima (2020) Sialic acid sulfation is induced by the antibiotic treatment in mammalian cells. Bioscience, Biotechnology, and Biochemistry Published online (doi: 10.1080/09168451.2020.1792763)
2019年
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- Timklay W, Magerd S, Sato C, Somrit M, Watthammawut A, Senarai T, Weerachatyanukul W, Kitajima K, Asuvapongpatana S. (2019) N-linked mannose glycoconjugates on shrimp thrombospondin, pmTSP-II, and their involvement in the sperm acrosome reaction. Mol Reprod Dev. 86(4), 440-449 (doi: 10.1002/mrd.23122).
- Abe C, Yi Y, Hane M, Kitajima K, Sato C. (2019) Acute stress-induced change in polysialic acid levels mediated by sialidase in mouse brain. Sci Rep. 9(1), 9950 (doi: 10.1038/s41598-019-46240-6).
- Ikegami K, Saigoh K, Fujioka A, Nagano M, Kitajima K, Sato C, Masubuchi S, Kusunoki S, Shigeyoshi Y. (2019) Effect of expression alteration in flanking genes on phenotypes of St8sia2-deficient mice. Sci Rep. 9(1), 13634 (doi: 10.1038/s41598-019-50006-5).
- Lin CY, Lai HL, Chen HM, Siew JJ, Hsiao CT, Chang HC, Liao KS, Tsai SC, Wu CY, Kitajima K, Sato C, Khoo KH, Chern Y. (2019) Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D2 and adenosine A2Areceptors. Transl Psychiatry. 9(1), 209 (doi: 10.1038/s41398-019-0529-z).
2018年
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- Yamakawa N, Vanbeselaere, J. Chang, Lan-yi, Yu Shin-yi, Ducrocq, L., Harduin-Lepers, A., Sato, C., Aoki-Kinoshita, KF., Khoo, KH., Kitajima, K., Guerardel Y. (2018) Systems glycomics of adult zebrafish identifies organ specific sialylation and glycosylation patterns. Nature Commun. 9, 4647.
- Fujito NT, Satta Y, Hane M, Matsui A, Yashima K, Kitajima K, Sato C, Takahata N, Hayakawa T. (2018) Positive selection on schizophrenia-associated ST8SIA2 gene in post-glacial Asia. PLoS One, 13, e0200278.
2017年
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- Wu D*, Fujita A**, Hamaguchi K, Delannoy P, Sato C, Kitajima K.
Diverse subcellular localizations of the insect CMP-sialic acid synthetases.
Glycobiology. pp.1-13(2017) (doi: https://doi.org/10.1093/glycob/cww128)
- Ohira S, Yasuda Y, Tomita I, Kitajima K, Takahashi T, Sato C, Tanaka H.
Synthesis of End-functionalized Glycopolymers Containing α(2,8) Disialic Acids by π-Allyl Nickel Catalyzed Coordinating Polymerization and Their Interaction with Siglec-7.
Chem. Commun. 53(3), 553-556(2017) (doi: 10.1039/C6CC07115E)
- Go S**, Go S*, Veillon L, Ciampa MG, Mauri L, Sato C, Kitajima K, Prinetti A, Sonnino S, Inokuchi JI.
Altered expression of ganglioside GM3 molecular species and a potential regulatory role during myoblast differentiation.
J Biol Chem. 292(17), 7074-7051. (2017) (doi: 10.1074/jbc.M116.771253)
- Yamaguchi S#, Yoshimura A#*, Yasuda Y**, Mori A*, Tanaka H, Takahashi T, Kitajima K, Sato C.
Chemical synthesis and evaluation of a disialic acid-containing dextran polymer as an inhibitor for the interaction between Siglec 7 and its ligand.
ChemBioChem. 11, 1-11 (2017)(doi: 10.1002/cbic.201600694) #Equal contribution as the first author
- Senarai T, Vanichviriyakit R, Miyata S**, Sato C, Sretarugsa P, Weerachatyanukul W, Kitajima K.
Alpha-2 macroglobulin as a region-specific secretory protein in male reproductive tract and its dynamics during sperm transit towards female spermatheca in the blue crab.
Mol Reprod Dev. 84(7), 585-595 (2017) (doi: 10.1002/mrd.22817)
- Abe C*, Nishimura S**, Mori A*, Niimi Y**, Yang Y*, Hane M**, Kitajima K, Sato C.
Chlorpromazine increases the expression of polySia in human neuroblastoma cells and mouse prefrontal cortex.
International Journal of Molecular Science 18(6), pii: E1123. (2017) (doi: 10.3390/ijms18061123)
- Mori A*, Hane M**, Niimi Y**, Kitajima K, Sato C.
Different properties of polysialic acids synthesized by the polysialyltransferases ST8SIA2 and ST8SIA4.
Glycobiology 27(9), 834-846 (2017) (doi: 10.1093/glycob/cwx057)
2016年
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- Hane M**, Kitajima K, Sato C.
Effects of intronic single nucleotide polymorphisms (iSNPs) of a polysialyltransferase, ST8SIA2 gene found in psychiatric disorders on its gene products.
Biochem Biophys Res Commun. 478(3), 1123-1129. (2016) (doi: 10.1016/j.bbrc.2016.08.079)
- Mizukami AG, Inatsugi R, Jiao J, Kotake T, Kuwata K, Ootani K, Okuda S, Sankaranarayanan S, Sato Y, Maruyama D, Iwai H, Garénaux E, Sato C, Kitajima K, Tsumuraya Y, Mori H, Yamaguchi J, Itami K, Sasaki N, Higashiyama T.
The AMOR Arabinogalactan Sugar Chain Induces Pollen-Tube Competency to Respond to Ovular Guidance.
Curr Biol. 26(8), 1091-1097.(2016) (doi: 10.1016/j.cub.2016.02.040)
2015年
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- Garénaux E, Kanagawa M, Tsuchiyama T, Hori K, Kanazawa T, Goshima A, Chiba M, Yasue H, Ikeda A, Yamaguchi Y, Sato C, and Kitajima K.
Discovery, primary and crystal structures, and capacitation-related properties of a prostate-derived heparin-binding protein WGA16 from boar sperm.
J. Biol. Chem. 290(9). 5484-5501 (2015) (doi: 10.1074/jbc.M114.635268)
- Sumida M, Hane M, Yabe U, Shimoda Y, Pearce OM, Kiso M, Miyagi T, Sawada M, Varki A, Kitajima K, and Sato C.
Rapid trimming of cell surface polySia by exovesicular sialidase triggers release of preexisting surface neurotrophin. J. Biol. Chem. 290:13202-14.(2015) doi: 10.1074/jbc.M115.638759.
- Hane M, Matsuoka S, Miyata S. Kitajima K and Sato C.
Protective effects of polysialic acid on proteolytic cleavage of FGF2 and proBDNF/BDNF.
Glycobiology. 10:1112-24. doi: 10.1093/glycob/cwv049. (2015)
- Kitajima K, Varki N, Sato C.
Advanced technologies in sialic acid and sialoglycoconjugate anaysis.
Top Curr Chem. 2015;367:75-103. doi: 10.1007/128_2013_458
- Harada Y, Sato C, Kitajima K.
Sulfatide-Hsp70 interaction promotes Hsp70 clustering and stabilizes binding to unfolded protein.
Biomolecules.2015 May 15;5(2):958-73. doi: 10.3390/biom5020958.
- Kobayashi Y, da Silva R, Kumanogoh H, Miyata S, Sato C, Kitajima K, Nakamura S, Morita M, Hayashi F, Maekawa S.
Ganglioside contained in the neuronal tissue-enriched acidic protein of 22 kDa (NAP-22) fraction prepared from the detergent-resistant membrane microdomain of rat brain inhibits the phosphatase activity of calcineurin.
J Neurosci Res. 2015 Sep;93(9):1462-70. doi: 10.1002/jnr.23599.
2014年
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- Harada Y, Garenaux E, Nagatsuka T, Uzawa H, Nishida Y, Sato C, and Kitajima K.
Interaction of 70-kDa heat shock protein with glycosaminoglycans and acidc glycopolymers.
Biochem Biophys Res Commun. 453, 229-234. (doi: 10.1016/j.bbrc.2014.05.137)
- Nishimura S, Hane M, Niimi Y, Miyata S, Kitajima K, and Sato C.
Comparison of analytical methods to detect polysialic acid.
Journal of Glycomics and Lipidomics 4(2), 113. (2014) (doi: 10.4172/2153-0637.1000113)
- Ikegami K, Liao X-H, Hoshino Y, Ono H, Ota W, Ito Y, Nishiwaki-Ohkawa T, Sato C, Kitajima K, Iigo M, Shigeyoshi Y, Yamada M, Murata Y, Refetoff S, Yoshimura T.
Tissue-specific post-translational modification allows functional targeting of thyrotropin.
Cell Reports 9(6), 1-9(2014)
- Colley K., Kitajima K, Sato C.
Polysialic acid: Biosynthesis, novel functions and applications.
Critical Reviews in Biochemistry and Molecular Biology 1-35 doi:10.3109/10409238.2014.976606
- Ken Kitajima
136 N-acetylneuraminic acid 9-phosphatase (NANP).
Handbook of Glycosyltransferases and related genes(eds., Taiguchi N, Honke K, Fukuda M, Narimatsu H, Yamaguchi Y, Angata T), p136, Springer.(2014)
- Chihiro Sato
70 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 (ST8SIA2)
Handbook of Glycosyltransferases and related genes (eds., Taiguchi N, Honke K, Fukuda M, Narimatsu H, Yamaguchi Y, Angata T), Springer.(2014)
- Sato, C.
Frontal Affinity Chromatography in the Methods in Molecular Biology(Lectins: Ed. Hirabayashi, J.)
Springer, Germany, pp257-264.
- Sato, C. and Kitajima, K.
Polysialic acid in the Glycoscience: Biology and Medicine (Taniguchi, N., Honke, K., Fukuda, M., Yamaguchi, Y., and Angata, T. eds.),
Springer, Germany, pp.1-7. Doi: 10.1007/SpringerReference_395554(2014)
- Hane, M., Kitajima, K. and Sato, C.
Polysialyltransferase assay in the Glycoscience: Biology and Medicine (Taniguchi, N., Honke, K., Fukuda, M., Yamaguchi, Y., and Angata, T. eds.),
Springer, Germany,pp.1-5. DOI: 10.1007/SpringerReference_395557 (2014)
- Kanazawa, T., Suzuki, E., Miyata, S., Sato, C. and Kitajima, K.
Flagellasialin in the Glycoscience: Biology and Medicine (Taniguchi, N., Honke, K., Fukuda, M., Yamaguchi, Y., and Angata, T. eds.),
Springer, Germany, pp.1-6. DOI: 10.1007/SpringerReference_396268(2014)
2013年
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- Akasaka M, Kato KH, Kitajima K, Sawada H.
Identification of novel isoforms of vitellogenin expressed in ascidian eggs.
J Exp Zool Part B Mol Dev Evol. 320(2), 118-128. (2013)
- Yabu M, Korekane H, Takahashi H, Ohigashi H, Ishikawa O, Hatano K, Nonomura N, Sato C, Kitajima K, Miyamoto Y.
Occurrence of free deaminoneuraminic acid (KDN)-containing complex-type N-glycans in human prostate cancers.
Glycobiology 23(6), 634-642. (2013) (doi: 10.1093/glycob/cws132)
- Hanashima S, Sato C, Tanaka H, Takahashi T, Kitajima K, Yamaguchi Y.
NMR study into the mechanism of recognition of the degree of polymerization by oligo/polysialic acid antibodies.
Bioorg. Med. Chem. 21(19), 6069-76. (doi: 10.1016/j.bmc.2013.07.023) Oct 1. (2013)
- Nagae M, Ikeda A, Hane M, Hanashima S, Kitajima K, Sato C, Yamaguchi Y.
Crystal structure of anti-polysialic acid antibody single chain Fv fragment complexed with octasialic acid: insight into the binding preference for polysialic acid.
J Biol Chem. 288(47), 33784-96. (doi: 10.1074/jbc.M113.496224) ; 2013 Oct 7. (2013)
- Sato C, Kitajima K.
Impact of structural aberrancy of polysialic acid and its synthetic enzyme ST8SIA2 in schizophrenia.
Front. Cell. Neurosci. 7, 61 (1-11) (2013) (doi: 10.3389/fncel.2013.00061)
- Sato C., Kitajima K.
Disialic, oligosialic, and polysialic acids: Distribution, biological functions, and related disease.
J Biochem (Tokyo). 154(2), 115-136. (2013) (doi: 10.1093/jb/mvt057)
- 佐藤ちひろ、北島健
ポリシアル酸による神経機能の調節.
実験医学 31巻 10号 (増刊) pp. 26-33; 第三の生命鎖:糖鎖の機能と疾患(門松健治、遠藤玉夫、岡昌吾、北川裕之編集)羊土社(2013)
2012年
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- Ono S, Hane M, Kitajima K, Sato C.
Novel regulation of fibroblast growth factor 2 (FGF2)-mediated cell growth by polysialic acid.
J Biol Chem. 287(6), 3710-3722.(2012)
- Guérardel Y, Chang LY, Fujita A, Coddeville B, Maes E, Sato C, Harduin-Lepers A, Kubokawa K, Kitajima K.
Sialome analysis of the cephalochordate Branchiostoma belcheri, a key organism for vertebrate evolution.
Glycobiology 22(4), 479-491.(2012)
- Hane M, Sumida M, Kitajima K, Sato C.
Structural and functional impairments of polySia-NCAM synthesized by a mutated polysialyltransferase of a schizophrenic patient.
Pure Appl Chem. in press.
- Takahashi K, Mitoma J, Hosono M, Shiozaki K, Sato C, Yamaguchi K, Kitajima K, Higashi H, Nitta K, Shima H, Miyagi T.
Sialidase NEU4 hydrolyzes polysialic acids of neural cell adhesion molecules and negatively regulates neurite formation by hippocampal neurons.
J Biol Chem. in press
- Sato C.
Polysialic acids (Review). in Sialobiology: Structure, Function and Biosynthesis (Tiralongo J ed) Bentham Science in press
2011年
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- Isomura R, Kitajima K, and Sato C.
Structural and functional impairments of polysialic acid by a mutated polysialyltransferase found in schizophrenia
J. Biol. Chem. 286(24), 21535–21545. (2011)
- Miyata S, Yamakawa N, Toritama M, Sato C, Kitajima K.
Co-expression of two distinct polysialic acids, α2,8- and α2,9-linked polymers of N-acetylneuraminic acid, in distinct glycoproteins and glycolipids in sea urchin sperm.
Glycobiology 21(12), 1596-1605. (2011)
- Inoue S, Kitajima K, Sato C, Go S.
Human KDN (deaminated neuraminic acid) and its elevated expression in cancer cells: mechanism and significance.
Adv Exp Med Biol. 705, 669-678. (2011)
- Kambara Y, Shiba K, Yoshida M, Sato C, Kitajima K, Shingyoji C.
Mechanism regulating Ca2+-dependent mechanosensory behaviour in sea urchin spermatozoa.
Cell Struct Funct. 36(1), 69-82. (2011)
- Sato C, Kitajima K.
New function of polysialic acid and its involvement in neural activities.
Seikagaku 83(3), 189-196. (2011)
- Sato C, Kitajima K.
New function of polysialic acid and its relationship to schizoprenia.
Trends Glycsci Glycotech 23(133), 221-238. (2011)
- Kitajima K, Sato C.
The roles of carbohydrate binding in cell adhesion and inflammation.
in Carbohydrate Recognition: Biological problems, methods, and applications (eds., Binghe Wang, Geer-Jan Boons), pp33-63; John Wiley and Sons (2011)
2010年
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- Inoue, S., Sato, C. and Kitajima, K.
Extensive enrichment of N-glycolylneuraminic acid in extracellular sialoglycoproteins abundantly synthesized and secreted by human cancer cells.
Glycobiology, 20, 752-762 (2010)
- Inoko, E., Nishiura, Y., Tanaka, H., Takahashi, T., Furukawa, K., Kitajima, K., and Sato, C.
Developmental stage-dependent expression of an a2,8-trisialic acid unit on glycoproteins in mouse brain.
Glycobiology, 20, 752-762 (2010)
- Sato, C.
SEITAINOKAGAKU, 61, 160-166.(2010)
- Sato, C., Yamakawa, N., and Kitajima, K.
Analysis of glycan-protein interaction by frontal affinity chromatography and Biacore.
in Methods in Enzymology (Minoru Fukuda ed. in glycomics) Elsevir science, 478, 219-232 (2010)
- Sano K, Miyamoto Y, Kawasaki N, Hashii N, Itoh S, Murase M, Date K, Yokoyama M, Sato C, Kitajima K, Ogawa H.
urvival signals of hepatic stellate cells in liver regeneration are regulated by glycosylation changes in rat vitronectin, especially decreased sialylation.
J. Biol. Chem., 285, 17301-17309 (2010)
2009年
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- Adachi T., Sato, C., Kishi, Y., Totani, K., Murata, T., Usui, T., and Kitajima, K
Membrane microdomains from early gastrula embryos of medaka, Oryzias latipes are a plat form of E-cadherin and carbohydrate-mediated cell-cell interactions during epiboly
Glycoconjugate J. 26: 285-299. (2009)
- Chang LY, Harduin-Lepers A, Kitajima K, Sato C, Huang CJ, Khoo KH, Guérardel Y.
Developmental regulation of oligosialylation in zebrafish.
Glycoconjugate J. 26: 247-261. (2009)
- Kanato, Y., Ono, S., Kitajima, K., and Sato, C.
Complex Formation of a Brain-Derived Neurotrophic Factor and Glycosaminoglycans.
Biosci. Biotech. and Biochem. 299-302, 73: 2735-2741. (2009)
2008年
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- Sato, C.
Chemical labeling of sialyloligo/polymer.
in Glycoscience Lab Manual (Taniguchi N, Suzuki A, Ito Y, Narimatsu H, Kawasaki T, Hase S, eds), 24-27, Springer, Japan (2008)
- Adachi, T., Sato, C. and Kitajima, K.
Membrane microdomain as a platform of carbohydrate-mediated interaction during early development of medaka fish.
in Glycoscience Lab Manual (Taniguchi N, Suzuki A, Ito Y, Narimatsu H, Kawasaki T, Hase S, eds), 299-302, Springer, Japan (2008)
- Kanato, Y., Kitajima, K. Sato, C.
Direct binding of polysialic acid to a brain-derived neurotrphic factor depends on the degree of polymerization.
Glycobiology 12:1044-1053 (2008)
- Sato, C, and Kitajima,
K PNE,53, 1577-1583 (2008).
2007年
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- Harada Y, Sato C, Kitajima K.
Complex formation of 70-kDa heat shock protein with acidic glycolipids and phospholipids.
Biochem Biophys Res Commun. 353, 655-660 (2007)
- Yasukawa, Z., Sato, C., and Kitajima, K.
Identification of an inflammation-inducible serum protein recognized by anti-disialic acid antibodies as carbonic anhydrase II.
J Biochem. 141, 429-441 (2007)
- Fujita, A, Sato C, and Kitajima K.
Identification of the nuclear export signals that regulate the intracellular localization of the mouse CMP-sialic acid synthetase.
Biochem Biophys Res Commun. 355, 174-180(2007)
- Go, S., Sato, C., Yin, J., Kannagi, R. and Kitajima, K.
Hypoxia-enhanced expression of free deaminoneuraminic acid in human cancer cells.
Biochem Biophys Res Commun. 355, 537-542 (2007).
- Miyata, S., Sato, C. and Kitajima, K.
Glycobiology of polysialic acids on sea urchin gametes.
Trends Glycosci. Glycotech. 19, 83-95.(2007)
- Yamakawa, N., Sato C., Miyata, S., Maehashi, E., Toriyama, T., Sato, N., Furuhata, K. and Kitajima. K.
Development of sensitive chemical and immunochemical methods for detecting sulfated sialic acids and their application to glycoconjugates from sea urchin sperm and eggs.
Biochimie, 89, 1396-1408 .(2007)
- Adachi, T., Sato, C. and Kitajima, K.
Membrane microdomain formation is crucial in epiboly during gastrulation of medaka.
Biochem. Biophys. Res. Commun., 358, 848-853(2007).
- Kitajima, K. Go, S. Fujita, A., and Sato, C.
SAIBOUKOUGAKU, 26, 629-634.(2007)
2006年
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- Yusa, A., Kitajima, K., and Habuchi, O.
N-Linked oligosaccharides on chondroitin 6-sulfotransferase-1 are required for production of the active enzyme, golgi localization, and sulfotransferase activity toward keratan sulfate.
J. Boil. Chem 281, 20393-20403 (2006)
- Yin, J., Hashimoto, A., Izawa, M., Miyazaki, K., Chen G-Y., Takematsu, H., Kozutsumi, Y., Suzuki, A., Furuhata, K., Cheng, F.-L. Lin, C.-H., Sato, C., Kitajima, K., and Kannagi, R.
Hypoxic culture induces expression of Sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells.
Cancer Res., 66, 2937-2945(2006).
- Nakatani H, Aoki N, Nakagawa Y, Jin-No S, Aoyama K, Oshima K, Ohira S, Sato C, Nadano D, Matsuda T.
Weaning-induced expression of a milk-fat globule protein, MFG-E8, in mouse mammary glands, as demonstrated by the analyses of its mRNA, protein and phosphatidylserine-binding activity.
Biochem J., 395, 21-30(2006).
- Go, S., Sato, C., and Kitajima, K.
Oral ingestion of mannose alters the expression level of deaminoneuraminic acid (KDN) in mouse organs.
Glycoconjugate J. 23, 411-421(2006)
- Kitajima, K. and Inoue, S
KDN (Deaminated neuraminic acid): Dreamful past and exciting future of the newest member of the sialic acid family.
Glycoconjugate J. 23, 277-290 (2006).
- Yasukawa, Z., Sato, C., Sano, K., Ogawa, H. and Kitajima, K.
Identification of disialic acid-containing glycoproteins in mouse serum.
Glycobiology 15, 827-837(2006)
- Miyata S, Sato C, Kumita H, Toriyama M, Vacquier VD, Kitajima K.
Flagellasialin: a novel sulfated alpha2,9-linked polysialic acid glycoprotein of sea
urchin sperm flagella.
Glycobiology 16, 1229-12241(2006)
- Asahina S, Sato C, Matsuno M, Matsuda T, Colley K, Kitajima K.
Involvement of the alpha2,8-polysialyltransferases II/STX and IV/PST in the biosynthesis of polysialic acid chains on the O-linked glycoproteins in rainbow trout ovary.
J Biochem. 140, 687-701(2006)
- 北島健
精子表面の糖脂質の役割.
新編精子学、665-673 (東京大学出版会) (2006)
2005年
-
- Tajima, Y., Uyama, E., Go, S., Sato, C., Tao, N., Kotani, M., Hino, H., Suzuki, A., Sanai, Y., Kitajima, K., and Sakuraba, H.
Distal Myopathy with Rimmed Vaculoes.
Am. J. Pathol. 166, 1121-1128 (2005)
- Haselhorst, T., Munster-Kuhnel, A.-K., Stolz, A., Oschlies, M., Tiralongo, J., Kitajima K, Gerardy-Schahn, R., and von Itzstein, M.
Probing a CMP-Kdn synthetase by 1H, 31P and STD NMR spectroscopy.
Biochem. Biophys. Res. Commun., 327, 565-570 (2005)
- Yusa, A., Kitajima, K., and Habuchi, O.
N-linked oligosaccharides are required to produce and stabilize the active form of chondroitin 4-sulfotransferase-1.
Biochem. J., 388, 115-121(2005)
- Yasukawa, Z., Sato, C., and Kitajima, K.
Inflammation-dependent changes in a2,3-, a2,6-, and a2,8-sialic acid glycotopes on serum glycoproteins in mouse.
Glycobiology, 15, 827-837(2005)
- 佐藤ちひろ、北島 健
4)ポリシアル酸. 5糖鎖と発生.
遺伝子医学MOOK 3 糖鎖と病気, 186-191 (株式会社メディカルドゥ) (2005)
- 佐藤ちひろ
オリゴシアル酸の標識.
未来を拓く糖鎖科学 p12-13 (金芳堂) (2005)
- 北島 健
ポリシアル酸の構造解析.
未来を拓く糖鎖科学 p39-40 (金芳堂) (2005)
- 北島 健
メダカ初期胚における糖鎖に富む生体膜マイクロドメインの役割.
未来を拓く糖鎖科学 p336-338 (金芳堂) (2005)
2004年
-
- T.Nishikawa, S. Kajii, C. Sato, Z. Yasukawa, K. Kitajima, and M. Isobe
alpha-C-Mannosyltryptophan is not recognized by conventional mannose-binding lectins
Bioorg Med Chem. 12 2343-2348 (2004)
- 佐藤ちひろ
ジシアル酸・オリゴシアル酸・ポリシアル酸の生物学的機能
Functional Glycomics 3 40-47 (2004)
- S. Miyata, C. Sato, S. Kitamura, S. Toriyama, and K. Kitajima,
A major flagellum sialoglycoprotein in sea urchin sperm contains a novel polysialic acid, an a2,9-linked poly-N-acetylneuraminic acid chain, capped by an 8-O-sulfated sialic acid residue
Glycobiology 14 827-840 (2004)
- S. Asahina, C.Sato, and K. Kitajima
Developmental Expression of a Sialyltransferase Responsible for Sialylation of Cortical Alveolus Glycoprotein During Oogenesis in Rainbow Trout (Oncorhynchus mykiss)
J. Biochem. 136,189-198(2004)
- C.Sato,
Chain length diversity of sialic acids and its biological significance (Review)
Trends Glycosci. Glycotechnol 16, 331-344(2004)
- A. Fujita, C. Sato, A.-K. Münster-Kühnel, R. Gerardy-Schahn, and K. Kitajima
Development of a simple and efficient method for assaying the CMP-sialic acid synthetase activity using an enzymatic NADH/NAD+converting system
Anal. Biochem. 337, 12-21 (2004)
- H. Okumura, Y. Kohno, Y. Iwata, H. Mori, N. Aoki, C. Sato, K. Kitajima, D. Nadano and T. Matsuda,
A newly identified zona pellucida glycoprotein, ZPD and dimeric ZP1 of chicken egg envelope are involved in sperm activation on sperm-egg interaction
Biochem. J. 383 1-9 (2004)
- 北島 健
受精・発生と糖鎖認識の研究における最近の発展.
生化学, 76,191-200 (2004)
- Nikonova, E. Y., Tertov, V. V., Sato, C., Kitajima, K., and Bovin, N. V.
Specificity of human trans-sialidase as probed with gangliosides.
Bioorg. Med. Chem. Lett., 14, 5161-5164 (2004)
2003年
-
- U. Yabe, C. Sato, T. Matsuda, and K. Kitajima
Polysialic acid in human milk
J. Biol. Chem. 278 13875-13880 (2003)
- E. Maehashi, C. Sato, K. Ohta, Y. Harada, T., Matsuda, N. Hirohashi, W. J. Lennarz, and K. Kitajima
Identification of the sea urchin 350 kDa sperm binding protein as a new sialic acid-binding lectin that belongs to the heat shock protein 110 family.
J. Biol. Chem. 278 42050-42057 (2003)
- 佐藤ちひろ、北島 健
糖タンパク質と糖脂質の共通糖鎖オリゴシアル酸の普遍的存在とその意義
蛋白質・核酸・酵素 48 1730-1736 (2003)
- 佐藤ちひろ
ポリシアル酸の鎖長多様性とタンパク質機能 (Review)
生化学 75 1526-1530 (2003)
2002年
-
- Sato, C., Matsuda, T., and Kitajima, K.
Neuronal differentiation-dependent expression of the disialic acid epitope on CD166 and its involvement in neurite formation in Neuro2A cells.
J. Biol. Chem. 277,.45299-45305 (2002)
- Suzuki, T., Yano, K., Sugimoto, S., Kitajima, K., Lennarz, W. J., Inoue, S., Inoue, Y., and Emori, Y.
Endo-beta-N-acetylglucosaminidase, an enzyme involved in processing of free oligosaccharides in the cytosol.
Proc. Natl. Acad. Sci. USA 99, 9691-9696. (2002)
- Matsuura, K., Kitakouji, H., Oda, R., Morimoto, Y., Asano, H., Ishida, H., Kiso, M., Kitajima, K., and Kobayashi, K.
Selective expansion of the GM3 glycolipid monolayer induced by carbohydrate-carbohydrate interaction with Gg3 trisaccharide-bearing glycoconjugate polystyrene at the air-water interface.
Langmuir 18, 6940-6945. (2002)
- Oshima, K., Aoki, N., Kato, T., Kitajima, K., and Matsuda, T.
Secretion of a peripheral membrane protein, MFG-E8, as a complex with membrane vesicles. A possible role in membrane secretion.
Eur. J. Biochem. 269, 1209-1218. (2002)
- 北島 健
ナノスケールで語る新しい細胞膜像
化学 57巻, No. 3、化学同人、pp.24-29.(2002)
2001年
-
- D. Nakata, A.-K. Münster, R. Gerardy-Schahn, N. Aoki, T. Matsuda, and K. Kitajima
Molecular cloning of a unique CMP-sialic acid synthetase which effectively utilizes both deaminoneuraminic Acid (KDN) and N-acetylneuraminic acid (Neu5Ac) as substrates.
Glycobiology11, 685-692 (2001)
- C. Sato, Z. Yasukawa, N. Honda, T. Matsuda, and K. Kitajima
Identification and adipocyte differentiation-dependent expression of the unique disialic acid residue in an adipose tissue-specific glycoprotein, adipo Q.
J. Biol. Chem. 276, 28849-28856 (2001a)
- S. Nadanaka, C. Sato, K. Kitajima, K. Katagiri, S. Irie, and T. Yamagata
Occurrence of oligosialic acids on integrin alpha-5 subunit and thier involvement in cell adhesion to fibronectin.
J. Biol. Chem. 276, 33657-33664 (2001b)
- Y. Takeuchi, R. Cho, Y. Iwata, K. Nishimura, T. Kato, N. Aoki, K. Kitajima, and T. Matsuda
Morphological and biochemical changes of isolated chicken egg-envelope during sperm penetration: Degradation of the 97 kilodalton glycoprotein is involved in sperm-driven hole formation on the egg-envelope.
Biol. Reprod. 64, 822-830(2001)
- Y. Usui, M. Nakase, H. Hotta, A. Urisu, N. Aoki, K. Kitajima, and T. Matsuda
A 33-kDa allergen from rice (Oryza sativa L. Japonica). cDNA cloning, expression, and identification as a novel glyoxalase I.
J. Biol. Chem. 276, 11376-11381 (2001)
2000年
-
- C. Sato, H. Fukuoka, K. Ohta, T. Matsuda, R. Koshino, K. Kobayashi, F.
A. Troy II, and K. Kitajima
Frequent occurrence of pre-existing a2®8-linked disialic and oligosialic acids with chain lengths up to 7 Sia residues in mammalian brain glycoproteins: Prevalence revealed by highly sensitive chemical methods and anti-di-, oligo, and polysialic acid antibodies specific for defined chain lengths.
J. Biol. Chem. 275, 15422-15431 (2000)
- K. Ohta, C. Sato, T. Matsuda, M. Toriyama, V. D. Vacquier, W. J. Lennarz, and K. Kitajima
Co-localization of receptor and transducer proteins in the glycosphingolipid-enriched, low density, detergent-insoluble membrane fraction of sea urchin sperm.
Glycoconjugate Journal 17, 205-214 (2000)
- D. Nakata, B. E. Close, K. J. Colley, T. Matsuda, and K. Kitajima
Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which has not the deaminoneuraminic acid (KDN) 9-phosphate synthase activity.
Biochem. Biophys. Res. Commun. 273, 642-648 (2000)
- K. Matsuura, H. Kitakouji, N. Sawada, Ishida, M. Kiso, K. Kitajima, K. Kobayashi
A quantitative estimation of carbohydrate-carbohydrate interaction using clustered oligosaccharide chains of glycolipid monolayers and of artificial glycoconjugate polymers by surface plasmon resonance
J. Am. Chem Soc. 122, 1406-1407 (2000)
1999年
-
- K. Oshima, N. Aoki, M. Negi, M. Kishi, K. Kitajima, and T. Matsuda
Lactation-dependent expression of an mRNA splice variant with an exon for a multiply O-glycosylated domain of mouse milk fat glubule glycoprotein MFG-E8
Biochem. Biophys. Res. Commun. 254, 522-528 (1999)
- T. Takeuchi, K. Nishimura, N. Aoki, T. Adachi, C. Sato, K. Kitajima, and T. Matsuda
A 42-kDa glycoprotein from chicken egg-envelope, an avian homolog of the ZPC family glycoproteins in mammalian zona pellucida. Its first identification, cDNA cloning and granulosa cell-specific expression.
Eur. J. Biochem.273, 21526-21530 (1999)
- A. Seko, K. Kitajima, T. Iwamatsu, S. Inoue, and Y. Inoue
Identification of two discrete peptide:N-glycanases in Oryzias latipes during embryogenesis.
Glycobiology 9, 887-895 (1999)
- S. Maekawa, C. Sato, K. Kitajima, H. Kumanogoh, N. Funatsu, and Y. Sokawa
Cholesterol-dependent localization of NAP-22 on a neuronal membrane microdomain (Raft).
J. Biol. Chem. 274, 21369-21374 (1999)
- C. Sato, S. Inoue, T. Matsuda, and K. Kitajima
Fluorescent-assisted detection of oligosialyl units in glycoconjugates.
Anal. Biochem. 267, 102-109 (1999)
- K. Ohta, C. Sato, T. Matsuda, M. Toriyama, W. J. Lennarz, and K. Kitajima
Isolation and characterization of low density detergent-insoluble membrane (LD-DIM) fraction from sea urchin sperm.
Biochem. Biophys. Res. Commun. 258, 616-623 (1999)
- K. Ohta, C. Sato, T. Matsuda, M. Toriyama, W. J. Lennarz, and K. Kitajima
Biosynthesis of KDN (2-keto-3-deoxy-d-glycero-d-galacto-nononic acid). Identification and Characterization of a KDN-9-phosphate Synthetase Activity from Trout Testis.
T. Angata, D. Nakata, T. Matsuda, F. A. Troy II, and K. Kitajima
J. Biol. Chem. 274, 22949-22956 (1999)
- T. Angata, D. Nakata, T. Matsuda, and K. Kitajima
Elevated expression of free deaminoneuraminic in mammalian cells cultured in mannose-rich media.
Biochem. Biophys. Res. Commun. 261, 326-331 (1999)
1998年
-
- M. Oubihi, K. Kitajima, K. Kobayashi, T. Adachi, N. Aoki, and T. Matsuda
Development of an enzyme-linked immunosorbent assay (ELISA)-based method for measuring galactosyltransferase activity using a synthetic glycopolymer acceptor substrate.
Anal. Biochem. 257, 169-175 (1998)
- C. Sato, K. Kitajima, S. Inoue, and Y. Inoue
Identification of oligo-N-glycolylneuraminic acid residues in mammal-derived glycoprotiens by a newly developed immunochemical reagent and biochemical methods.
J. Biol. Chem. 273, 2575-2582 (1998)
- M. Kudo, E. Takayama, K. Tashiro, H. Fukamachi, T. Nakata, T. Tadakuma, K. Kitajima, Y. Inoue, and K. Shiokawa
Cloning and expression of an a2,8-polysialyltransferase (STX) from Xenopus laevis.
Glycobiology 8, 771-777 (1998)
- T. Suzuki, H. Park, K. Kitajima, and W. J. Lennarz
Peptide glycosylated in the endoplasmic reticulum of yeast are subsequently deglycosylated by a soluble peptide: N-glycanase activity.
J. Biol. Chem. 273, 21526-21530 (1998)
- T. Angata, T. Matsuda, and K. Kitajima
Synthesis of neoglycoconjugates containing deaminated neuraminic acid (KDN) using rat liver a2,6-sialyltransferase.
Glycobiology 8, 277-284 (1998)
- S. Fuchizawa, K. Furuhata, T. Matsuda, and K. Kitajima
Induction of KDNase Sm, a deaminoneuraminic acid (KDN) residue-specific sialidase from Sphingobacterium multivorum, using synthetic KDN-glycosides.
Biochem. Biophys. Res. Commun. 248, 505-510 (1998)
- C. Sato, S. Inoue, T. Matsuda, and K. Kitajima
Development of a highly sensitive chemical method to detect a2®8-linked oligo/polysialic acid residues in glycoproteins blotted on the membrane.
Anal. Biochem. 261, 191-197 (1998)
1997年
-
- Y. Funakoshi, T. Taguchi, C. Sato, K. Kitajima, S. Inoue, H. R. Morris, A. Dell, and Y. Inoue
Occurrence of terminal a2®8-linked disialylated poly-N-acetyllactosamine chains with LeX and I antigenic glycotopes in tetraantennary arms of an N-linked glycoprotein isolated from rainbow trout ovarian fluid.
Glycobiology 7, 195-205 (1997)
- T. Terada, K. Kitajima, S. Inoue, J. C. Wilson, A. K. Norton, D. C. M. Kong, R. J. Thomson, M. von Itzstein, and Y. Inoue
Catalysis by a new sialidase, deaminoneuraminic acid residue-cleaving enzyme (KDNase Sm), initially forms a less stable a-anomer of 3-deoxy-D-glycero-D-galacto-nononic acid and is strongly inhibited by the transition state analogue, 2-deoxy-2,3-didehydro-D-glycero-D-galacto-2-nonulosonic acid, but not by 2-deoxy-2,3-didehydro-N-acetylneuraminic acid.
J. Biol. Chem. 272, 5452-5456 (1997)
- T. Taguchi, Y. Muto, K. Kitajima, S. Yokoyama, S. Inoue, and Y. Inoue
Proton NMR study of triantennary complex type N-linked glycan chains: assignment of protein chemical shifts of the b-Man residue in a basic unit of the triantennary glycan chain having a GlcNAcb1®6Mana1®6Manb1® sequence.
Glycobiology 7, 31-36 (1997)
- T. Taguchi, K. Kitajima, S. Inoue, Y. Inoue, J.-M. Yang, H. Schachter, and I. Brockhausen
Activity of UDP-GlcNAc: GlcNAcb1®6 (GlcNAcb1®2) Man1®R [GlcNAc to Man]b1®4N-acetyl glucosaminyl transferase VI (GnT VI) from the ovaries of Oryzias latipes (Medaka fish).
Biochem. Biophys. Res. Commun. 230, 533-536 (1997)
- T. Suzuki, K. Kitajima, Y. Emori, Y. Inoue, and S. Inoue
Site-specific de-N-glycosylation of diglycosylated ovalbumin in hen oviduct by endogenous peptide: N-glycanase as a quality control system for newly synthesized proteins.
Proc. Natl. Acad. Sci. USA 94, 6244-6249 (1997)
- L.-X. Wang, M. Tang, T. Suzuki, K. Kitajima, Y. Inoue, S. Inoue, J.-Q. Fan, and Y. C. Lee
Combined chemical and enzymatic synthesis of a C -glycopeptide and its inhibitory activity toward glycosaminidases.
J. Am. Chem. Soc. 119, 11137-11146 (1997)
1996年
-
- T. Ijuin, K. Kitajima, S. Yu, S. Kitazume, S. Inoue, S. M. Haslam, H. R. Morris, A. Dell, and Y. Inoue
Isolation and identication of novel sulfated and nonsulfated oligosialyl glycosphingolipids from sea urchin sperm.
Glycoconjugate Journal 13, 401-413 (1996)
- S. Nishino, H. Kuroyanagi, T. Terada, S. Inoue, Y. Inoue, F. A. Troy, II, and K. Kitajima
Induction, localization, and purification of a novel sialidase, deaminoneuraminidase (KDNase), from Sphingobacterium multivorum.
J. Biol. Chem. 271, 2909-2913 (1996)
- S. Kitazume, K. Kitajima, S. Inoue, S. M. Haslam, H. R. Morris, A. Dell, W. J. Lennarz, and Y. Inoue
The occurrence of novel 9-O-sulfated N-glycolylneuraminic acid-capped a2®5-Oglycolyl-linked oligo/polyNeu5Gc chains in sea urchin egg cell surface glycoprotein. Identification of a new chain termination signal for polysialyltransferase.
J. Biol. Chem. 271, 6694-6701 (1996)
- T. Terada, K. Kitajima, S. Inoue, K. Koppert, R. Brossmer, and Y. Inoue
Substrate specificity of rainbow trout testis CMP-KDN synthetase. Kinetic studies of the CMP-KDN synthetase-catalyzed reaction of natural and synthetic analogues of nonulosonic acid.
Eur. J. Biochem. 236, 852-855 (1996)
- M. Ziak, B. Qu, X. Zuo, C. Zuber, A. Kanamori, K. Kitajima, S. Inoue, Y. Inoue, and J. Roth
Occurrence of poly a2,8 deaminoneuraminic acid (KDN) in mammalian tissues: Widespread and developmentally-regulated but highly selective expression on glycoproteins.
Proc. Natl. Acad. Sci. U.S.A. 93, 2759-2763 (1996)
- T. Taguchi, M. Iwasaki, Y. Muto, K. Kitajima, S. Inoue, K.. Khoo, H. R. Morris, A. Dell, and Y. Inoue
Occurrence and precise structural analysis of highly sulfated multi-antennary N-linked glycan chains derived from a fertilization-associated carbohydrate-rich glycoprotein in unfertilized eggs of Tribolodon hakonensis.
Eur. J. Biochem., 238, 357-367 (1996)
- S. Inoue, K. Kitajima, and Y. Inoue
Identification of 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN, deaminoneur-aminic acid) residues in mammalian tissues and human lung carcinoma cells. Chemical evidence of the occurrence of KDN glycoconjugatess in mammals.
J. Biol. Chem. 271, 24341-24344 (1996)
- M. Kudo, K. Kitajima., S. Inoue, K. Shiokawa, H. R. Morris, A. Dell, and Y. Inoue.
Characterization of major core structures of the a2®8-linked polysialic acid-containing glycan chains present in neural cell adhesion molecule in embryonic chick brains.
J. Biol. Chem. 271, 32667-32677 (1996)
1995年
-
- T. Taguchi, K. Kitajima, Y. Muto, S. Yokoyama, S. Inoue, and Y. Inoue
Proton NMR study of the trimannosyl unit in a pentaantennary N-linked decasaccharide structure. Complete assignment of the proton resonances and conformational characterization.
Eur. J. Biochem, 288, 822-829 (1995)
- S. Yu, K. Kitajima, S. Inoue, K.-H. Khoo, H. R. Morris, A. Dell, and Y. Inoue
Expression of new KDN-gangliosides in rainbow trout testis during spermatogenesis and their structural identification.
Glycobiology 5, 207-218 (1995)
- T. Suzuki, K. Kitajima, S. Inoue, and Y. Inoue
N-Glycosylation/deglycosylation as a mechanism for the post-translational modification/re-modification of proteins.
Glycoconjugate Journal 12, 183-193 (1995)
- K. Kitajima, T. Suzuki, Z. Kouchi, S. Inoue, and Y. Inoue
Identification and distribution of peptide:N-glycanase (PNGase) in mouse organ.
Arch. Biochem. Biophys. 319, 393-401 (1995)
- T. Taguchi, K. Kitajima, T. Niimi, Y. Muto, S. Yokoyama, S. Inoue, and Y. Inoue
Complete assignment of carbon-13 NMR resonances to all the carbon atoms of the trimannosido-di-N-acetylchitobiosyl structure in a pentaantennary decasaccharide glycopeptide.
Carbohydr. Res. 275, 185-191 (1995)
- T. Suzuki, K. Kitajima, S. Inoue, and Y. Inoue
Carbohydrate-binding property of peptide:N-glycanase (PNGase) from mouse fibroblast L-929 cells as evaluated by inhibition and binding experiments using various oligosaccharides.
J. Biol. Chem. 270, 15181-15186 (1995)
- C. Sato, K. Kitajima, S. Inoue, T. Seki, F. A. Troy, II, and Y. Inoue
Characterization of the antigenic specificity of four different anti-(a2®8-linked polysialic acid) antibodies using lipid-conjugated oligo/polysialic acids
J. Biol. Chem. 270, 18923-18928 (1995)
- T. Taguchi, K. Kitajima, Y. Muto, S. Inoue, K.-H. Khoo, H. R. Morris, A. Dell, R. A. Wallace, K. Selman, and Y. Inoue
A precise structural analysis of a fertilization-associated carbohydrate-rich glycopeptide isolated from the fertilized eggs of euryhaline killi fish (Fundulus heteroclitus). Novel pentaantennary N-glycan chains with a bisecting N-acetylglucosaminyl residue
Glycobiology 5, 611-624 (1995)
1994年
-
- Y. Shimoda, K. Kitajima, S. Inoue, and Y. Inoue
Calcium ion binding of three different types of oligo/polysialic acids as studied by equilibrium dialysis and circular dichroic methods.
Biochemistry 33, 1202-1208 (1994)
- S. Kitazume, K. Kitajima, S. Inoue, Y. Inoue, and F. A. Troy, II
Developmental expression of trout egg polysialoglycoproteins and the prerequisite a2,6-, and a2,8-sialyl and a2,8-polysialyltransferase activities required for their synthesis during oogenesis.
J. Biol. Chem. 269, 10330-10340 (1994)
- T. Taguchi, A. Seko, K. Kitajima, Y. Muto, S. Inoue, K.. Khoo, H. R. Morris, A. Dell, and Y. Inoue
Structural studies of a novel type of pentaantennary large glycan unit in the fertilization-associated carbohydrate-rich glycopeptide isolated from the fertilized eggs of Oryzias latipes.
J. Biol. Chem. 269, 8762-8771 (1994)
- T. Tezuka, T. Taguchi, A. Kanamori, Y. Muto, K. Kitajima, Y. Inoue, and S. Inoue
Identification and structural determination of the KDN-containing N-linked glycan chains consisting of bi- and triantennary complex-type units of KDN-glycoprotein previously isolated from rainbow trout vitelline envelopes.
Biochemistry 33, 6495-6502 (1994)
- A. Kanamori, S. Inoue, Z. Xulei, C. Zuber, J. Roth, K. Kitajima, J. Ye, F. A. Troy, II, and Y. Inoue
Monoclonal antibody specific for a2®8-linked oligo deaminated neuraminic acid (KDN) sequences in glycoproteins. Preparation and characterization of a monoclonal antibody and its application in immunohistochemistry.
Histochemistry 101, 333-340 (1994)
- T. Suzuki, A. Seko, K. Kitajima, Y. Inoue, and S. Inoue
Purification and enzymatic properties of peptide: N-glycanase from C3H mouse-derived L-929 fibroblast cells. Possible widespread occurrence of post-translational remodification of proteins by N-deglycosylation.
J. Biol. Chem. 269, 17611-17618 (1994)
- T. Angata, K. Kitajima, S. Inoue, J. Chang, T. G. Warner, F. A. Troy II, and Y. Inoue
Identification, developmental expression and tissue distribution of deaminoneuraminate hydrolase (KDNase) activity in rainbow trout.
Glycobiology 4, 517-523 (1994)
- J. Ye, K. Kitajima, Y. Inoue, S. Inoue, and F. A. Troy II
Identification of polysialic acids in glycoconjugates.
Methods in Enzymology 230, 460-484 (1994)
- Y. Shimoda, K. Kitajima, S. Inoue, and Y. Inoue
Isolation, structural determination, and calcium-binding properties of the major glycoprotein present in Bufo japonicus japonicus egg jelly.
Eur. J. Biochem. 223, 223-231 (1994)
- K. Kitajima, H. Kuroyanagi, S. Inoue, J. Ye, F. A. Troy II, and Y. Inoue
Discovery of a new type of sialidase, “KDNase”, which specifically hydrolyzes deaminoneuraminyl (3-deoxy-D-glycero-D-galacto-2-nonulosonic acid) but not N-acylneuraminyl linkages.
J. Biol. Chem. 269, 21415-21419 (1994)
- S. Kitazume, K. Kitajima, S. Inoue, F. A. Troy II, J. Cho, W. J. Lennarz, and Y. Inoue
Identification of polysialic acid-containing glycoprotein in the jelly coat of sea urchin eggs. Occurrence of a novel type of polysialic acid structure.
J. Biol. Chem. 269, 22712-22718 (1994)
- T. Suzuki, K. Kitajima, S. Inoue, and Y. Inoue
Does an animal peptide:N-glycanase have the dual role as an enzyme and a carbohydrate-binding protein?
Glycoconjugate Journal 11, 469-476 (1994)
- T. Angata, S. Kitazume, T. Terada, K. Kitajima, S. Inoue, F. A. Troy II, and Y. Inoue
Identication, characterization, and developmental expression of a novel a-2®8-KDN-transferase which terminates elongation of a-2®8-linked oligo-polysialic acid chain synthesis in trout egg polysialoglycoproteins.
Glycoconjugate Journal 11, 493-499 (1994)
- S. Kitazume, K. Kitajima, S. Inoue, F. A. Troy II, W. J. Lennarz, and Y. Inoue
Differential reactivity of two types of N-glycolylneuraminic acid dimers toward enzymatic and nonenzymatic hydrolysis of their interglycosidic linkages.
Biochem. Biophys. Res. Commun. 205, 893-898 (1994)
- T. Suzuki, K. Kitajima, S. Inoue, and Y. Inoue
Occurrence and biological roles of ‘proximal glycanases’ in animal cells.
Glycobiology 4, 777-789 (1994)
1993年
-
- T. Terada, S. Kitazume, K. Kitajima, S. Inoue, F. Ito, F. A. Troy II, and Y. Inoue
Synthesis of CMP-deaminoneuraminic acid (CMP-KDN) using the CTP:CMP-3-deoxy-nonulosonate cytidylyltransferase from rainbow trout testis. Identification and characterization of a CMP-KDN synthetase.
J. Biol. Chem. 268, 2640-2648 (1993)
- S. Yu, K. Kitajima, and Y. Inoue
Monoclonal antibody specific to a-2®3-linked deaminated neuraminyl b-galactosyl sequence.
Glycobiology 3, 31-36 (1993)
- T. Taguchi, A. Seko, K. Kitajima, S. Inoue, T. Iwamatsu, K.-H. Khoo, H. R. Morris, A. Dell, and Y. Inoue
Structural studies of a novel type of tetraantennary sialoglycan unit in a carbohydrate-rich glycopeptide isolated from the fertilized eggs of Indian medaka fish, Oryzias melastigma.
J. Biol. Chem. 268, 2353-2362 (1993)
- T. Suzuki, A. Seko, K. Kitajima, Y. Inoue, and S. Inoue
Identification of peptide: N-glycanase activity in mammalian-derived cultured cells.
Biochem. Biophys. Res. Commun. 194, 1124-1130 (1993)
- S. Yu, K. Kitajima, S. Inoue, Y. Muto, T. Kasama, S. Handa, and Y. Inoue
Structure of novel gangliosides, deaminated neuraminic acid (KDN)-containing glycosphingolipids, isolated from rainbow trout ovarian fluid.
Biochemistry 32, 9221-9229 (1993)
- C. Sato, K. Kitajima, I. Tazawa, Y. Inoue, S. Inoue, and F. A. Troy, II
Structural diversity in a2®8-linked polysialic acid chains in salmonid fish egg glycoproteins. Occurrence of poly(Neu5Ac), poly(Neu5Gc), poly(Neu5Ac,Neu5Gc), poly(KDN), and their partially acetylated forms.
J. Biol. Chem. 268, 23675-23684 (1993)
- A. Kanamori, K. Kitajima, Y. Inoue, S. Inoue, K. Hoshino, E. Matsuoka, A. Sato, and K. Satsumi
Immunochemical method as early diagnosis for distinguishing salmonid fish female and male prior to genital maturation by use of a minute amount of blood collected from a single piece of gill filament.
Nippon Suisan Gakkaishi 59, 593-600 (1993)
1992年
-
- S. Kitazume, K. Kitajima, S. Inoue, and Y. Inoue
Detection, isolation, and characterization of oligo/poly (sialic acid) and oligo/poly (deamino-neuraminic acid) units in glycoconjugates.
Anal. Biochem. 202, 25-34 (1992)
- K. Kitajima, S. Inoue, S. Kitazume, and Y. Inoue
Analytical methods for identifying and quantitating deamidated sialic acid (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid) and a2®8-linked poly(oligo)nonulosonate residues in glycoconjugates.
Anal. Biochem. 205, 244-250 (1992)
- M. Iwasaki, A. Seko, K. Kitajima, Y. Inoue, and S. Inoue
Fish egg glycophosphoproteins have species-specific N-linked glycan units previously found in a storage pool of free glycan chains.
J. Biol. Chem. 267, 24287-24296 (1992)
1991年
-
- K. Ohkubo, A. Seko, K. Ishii, R. Shigematsu, K. Kitajima, Y. Inoue, M.Iwasaki, S. Inoue, F. Hayashi, S. Tejima, A. Sato, K. Satsumi, and N. Okumoto
Identification of rainbow trout of delayed maturity (3-year maturation) based on cortical alveolar glycoproteins (hyosophorin).
Nippon Suisan Gakkaishi 57, 1355-1364 (1991)
- A. Seko, K. Kitajima, S. Inoue, and Y. Inoue
Identification of free glycan chain liberated by de-N -glycosylation of the cortical alveolar glycoprotein (hyosophorin) during early embryogenesis of the medaka fish, Oryzias latipes.
Biochem. Biophys. Res. Commun. 180, 1165-1171 (1991)
- S. Yu, K. Kitajima, S. Inoue, and Y. Inoue
Isolation and structural elucidation of a novel type of ganglioside, deaminated neuraminic acid (KDN)-containing glycosphingolipid, from rainbow trout sperm. The first example of the natural occurrence of KDN-ganglioside, (KDN)GM3.
J. Biol. Chem. 266, 21929-21935 (1991)
- A. Seko, K. Kitajima, Y. Inoue, and S. Inoue
Peptide:N -glycosidase activity found in the early embryos of Oryzias latipes (medaka fish). The first demonstration of the occurrence of peptide: N -glycosidase in animal cells and its implication for the presence of a de-N -glycosylation system in living organisms.
J. Biol. Chem. 266, 22110-22114 (1991)
1990年
-
- S. Yu, K. Kitajima, and Y. Inoue
New tandem-repeating peptide structures in polysialoglycoproteins from the unfertilized eggs of kokanee salmon.
Arch. Biochem. Biophys. 283, 167-172 (1990)
- A. Kanamori, S. Inoue, M. Iwasaki, K. Kitajima, G. Kawai, S. Yokoyama, and Y. Inoue
Deaminated neuraminic acid-rich glycoprotein of rainbow trout egg vitelline envelope. Occurrence of a novel a-2,8-linked oligo (deaminated neuraminic acid) structure in O -linked glycan chains.
J. Biol. Chem. 265, 21811-21819 (1990)
1989年
-
- K. Kitajima, S. Inoue, and Y. Inoue
Isolation and characterization of a novel type of sialoglycoproteins (hyosophorin) from eggs of medaka, Oryzias latipes. Nonapeptide with a large N -linked glycan chain as a tandem repeat unit.
Develop. Biol. 132, 544-553 (1989)
- Y. Kurakata, H. Sakagami, M. Takeda, K. Konno, K. Kitajima, S. Ichikawa, N. Hata, and T. Sato
Mitogenic activity of pine cone extracts against cultured splenocyte from normal and tumor-bearing animals.
Anticancer Res. 9, 961-966 (1989)
- A. Seko, K. Kitajima, M. Iwasaki, S. Inoue, and Y. Inoue
Structural studies of fertilization-associated carbohydrate-rich glycoproteins (hyosophorin) isolated from the fertilized and unfertilized eggs of flounder, Paralichthys olivaceus. Presence of a novel pentaantennary N -linked glycan chain in the tandem repeating glycopeptide unit of hyosophorin.
J. Biol. Chem. 264, 15922-15929 (1989)
- S. Inoue, M. Iwasaki, K. Ishii, K. Kitajima, and Y. Inoue
Isolation and structures of glycoprotein-derived free sialooligosaccharide from the unfertilized eggs of Tribolodon hakonensis, a dace. Intracellular accumulation of a novel class of biantennary disialo-oligosaccharides.
J. Biol. Chem. 264, 18520-18526 (1989)
- A. Kanamori, K. Kitajima, S. Inoue, and Y. Inoue
Isolation and characterization of deaminated neuraminic acid-rich glycoprotein (KDN-gp-OF) in the ovarian fluid of rainbow trout (Salmo gairdneri).
Biochem. Biophys. Res. Commun. 164, 744-749 (1989)
- K. Fukuchi, H. Sakagami, T. Okuda, T. Hatano, S. Tanuma, K. Kitajima, Y. Inoue, S. Inoue, S. Ichikawa, M. Nonoyama, and K. Konno
Inhibition of herpes simplex virus infection by tannins and related compounds.
Antiviral Res. 11, 285-298 (1989)
1988年
-
- S. Inoue, A. Kanamori, K. Kitajima, and Y. Inoue
KDN-Glycoprotein: A novel deaminated neuraminic acid-rich glycoprotein isolated from vitelline envelope of rainbow trout eggs
Biochem. Biophys. Res. Commun. 153, 172-176 (1988)
- K. Kitajima, and S. Inoue
A proteinase associated with cortices of rainbow trout eggs and involved in fertilization-induced depolymerization of polysialoglycoproteins
Develop. Biol. 129, 270-274 (1988)
- K. Kitajima, H. Sorimachi, S. Inoue, and Y. Inoue
Comparative structures of the apopolysialoglycoproteins from unfertilized and fertilized eggs of salmonid fishes.
Biochemistry 27, 7141-7145 (1988)
- K. Kitajima, S. Inoue, Y. Inoue, and F. A. Troy, II
Use of bacteriophage-derived endo-N -acetylneuraminidase and an equine antipolysialyl antibody to characterize the polysialyl residues in salmonid fish egg polysialoglycoproteins
J. Biol. Chem. 263, 18269-18276 (1988)
- H. Sorimachi, Y. Emori, H. Kawasaki, K. Kitajima, S. Inoue, K. Suzuki, and Y. Inoue
Molecular cloning and characterization of cDNAs coding for apo-polysialoglycoprotein of rainbow trout eggs. Multiple mRNA species transcribed from multiple genes contain diverged numbers of exact 39-base (13-amino acid) repeats
J. Biol. Chem. 263, 17678-17684 (1988)
1987年
-
- S. Inoue, K. Kitajima, Y. Inoue, and S. Kudo
Localization of polysialoglycoprotein as a major glycoprotein component in cortical alveoli of the unfertilized eggs of Salmo gairdneri.
Develop. Biol. 123, 442-454 (1987)
1986年
-
- Polysialoglycoproteins of Salmonidae fish eggs. Complete structure of 200-kDa polysialoglycoprotein from the unfertilized eggs of rainbow trout (Salmo gairdneri).
K. Kitajima, Y. Inoue, and S. Inoue
J. Biol. Chem. 261, 5262-5269 (1986)
- D. Nadano, M. Iwasaki, S. Endo, K. Kitajima, S. Inoue, and Y. Inoue
A naturally occurring deaminated neuraminic acid, 3-deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN). Its unique occurrence at the nonreducing ends of oligosialyl chains in polysialoglycoprotein of rainbow trout eggs.
J. Biol. Chem. 261, 11550-11557 (1986)
1985年
-
- Y. Inoue and K. Kitajima
A mechanistic consideration of the hydrazinolysis of 3-O -substituted 2-acetamido-2-deoxy-D-hexopyranosyl and -D-hexitol residues in the absence and presence of hydrazinium sulfate.
Carbohydr. Res. 135, 342-347 (1985)
1984年
- K. Kitajima, H. Nomoto, Y. Inoue, M. Iwasaki, and S. Inoue
Fish egg polysialoglycoproteins: Circular dichroism and proton nuclear magnetic resonance studies of novel oligosaccharide units contaning one sialidase-resistant N -glycolylneuraminic acid residue in each molecule.
Biochemistry 23, 310-316 (1984)
- M. Iwasaki, S. Inoue, K. Kitajima, H. Nomoto, and Y. Inoue
Novel oligosaccharide chains on polysialoglycoproteins isolated from rainbow trout eggs. A unique carbohydrate sequence with a sialidase-resistant sialyl group, DGalNAcb1®4(NeuGc2®3)DGalNAc.
Biochemistry 23, 305-310 (1984)
- M. Iwasaki, H. Nomoto, K. Kitajima, S. Inoue, and Y. Inoue
Isolation and structures of the third major type of carbohydrate units in polysialoglycoproteins from rainbow trout eggs.
Biochemistry International 8, 573-579 (1984)
総説(Review)
2019年
-
- Sato C, Kitajima K. (2019) Sialic acids in neurology. Adv Carbohydr Chem Biochem. 76, 1-64 (doi: 10.1016/bs.accb.2018.09.003).
2017年
-
- Sato C.
Releasing mechanism of neurotrophic factors via polysialic acid.
Vitamines and Hormones. 104, 89-112.
- Sato C, Hane M**, Kitajima K.
Relationship between ST8SIA2, polysialic acid and its binding molecules, and psychiatric disorders.
Biochim Biophys Acta. 1860(8):1739-1752. (2016) (doi: 10.1016/j.bbagen.2016.04.015)
2016年
- Sato C, Hane M**, Kitajima K.
Relationship between ST8SIA2, polysialic acid and its binding molecules, and psychiatric disorders.
Biochim Biophys Acta. 1860(8):1739-1752. (2016) (doi: 10.1016/j.bbagen.2016.04.015)
著書(Books)
2020年
- 北島健、佐藤ちひろ、門松健治、加藤晃一編. (2020) 「糖鎖生物学」名古屋大学出版会
- Chihiro Sato, Masaya Hane, and Ken Kitajima (2020) Role of Polysialic Acid in Schizophrenia. in Comprehensive Glycoscience, 2nd Ed., Vol. *, Elsevier, (doi:10.1016/B978-0-12-819475-1.00026-2)
- Chihiro Sato and Ken Kitajima
Chapter 5. Polysialic acid as an integrative decoder in nervous and reproductive systems. in Glycome: The Hidden Code in Biology (Ed., Dipak K. Banerjee), May, 2021, in production, nova science publishers, USA. In press
2019年
- Kitajima K. (2019) Structural diversity and evolution of sialic acids. Trends Glycosci Glycotech. 31(181), E1-E3. (doi: 10.4052/tigg.1908.2E)
- Kitajima K. (2019) 4.11 Genetically Modified Small Fish (Zebrafish and Medaka). In Glycoscience: Basic science to applications – Insights from the Japan Consortium for Glycobiology and Glycotechnology (Taniguch N, Endo T, Hirabayashi J, Nishihara S, eds.), in press, Springer Nature Singapore Pte Ltd.
- Sato C. Kitajima K. (2019) Sialic Acids in Neurology: Advances in Carbohydrate Chemistry and Biochemistry. Sialic Acids. Vol.76, 1-64. (doi: org/10.1016/bs.accb.2018.09.003)
2018年
-
- Kitajima K. (2018) Identification of KDN-gangliosides. Methods Mol. Biol. 1804, 429-435. (doi: 10.1007/978-1-4939-8552-4_22)
- 佐藤ちひろ、北島健. (2018) ポリシアル酸化 (膜タンパク質; 特集 「タンパク質・核酸の分子修飾 Ⅲ. 細胞膜での分子修飾」)生体の科学 69巻5号 502-503.
- 北島健. (2018) 3-44 遺伝子改変:小型魚類 (3), 未来を創るグライコサイエンス:我が国のロードマップ (日本糖鎖科学コンソーシアム (JCGG) 編) pp 227-229, エム・ディー・オー.
- 佐藤ちひろ.
酸性糖鎖ポリシアル酸の新機能の発見とその応用展開. 化学と生物.
In press (2018)
2017年
- 羽根正弥**、北島健、佐藤ちひろ.
ポリシアル酸転移酵素遺伝子ST8SIA2と精神疾患の関わり.(特集「糖鎖関連遺伝子から眺める疾患」佐藤ちひろ、岡島徹也 編)
生化学. Vol.89, No 5. 634-643 (2017) (doi:10.14952/SEIKAGAKU.2017.890634)
- 佐藤ちひろ、岡島徹也.
特集「糖鎖関連遺伝子から眺める疾患」
生化学. Vol.89, No 5. 605-698.(2017)
- 原田陽一郎**、佐藤ちひろ、北島健.
Hsp70の酸性複合糖質結合活性の発見. 糖の意外な働き.
化学と生物. Vol. 55, No 1. pp.22-26(2017)
その他(e.t.c.)
受賞(Awards)
2023年
- 氏名:中川 貴博(生命農学研究科博士2年)
受賞名:第19回糖鎖科学中部拠点「若手の力フォーラム」 奨励賞
受賞年月日:2023年9月21日
対象演題:中川貴博、呉迪、羽根正弥、佐藤ちひろ、北島健
金属イオンが Kdn シアリダーゼ活性に及ぼす影響
- 氏名:中川 貴博(生命農学研究科博士2年)
受賞名:第96回日本生化学会大会若手優秀発表賞
受賞年月日:2023年10月31日-11月2日
対象演題:中川 貴博、岩木 佑弥、呉 迪、羽根 正弥、佐藤 ちひろ、北島 健.
Sphingobacterium属細菌由来新奇デアミノノイラミン酸 (Kdn) 特異的アルドラーゼの発見と酵素学的性質.
- 氏名:Wu Di(生物機能開発利用研究センター・糖鎖生命コア研究所 助教)
受賞名:The 2023 Meeting of the Society for Glycobiology ICSトラベル基金アワード
受賞年月日:2023年11月5-8日
2022年
- 氏名:大本 敬之(生命農学研究科博士2年)
受賞名: 卓越大学院プログラム (GTR) 優秀ポスター賞
受賞年月日:2022年1月7日
対象演題:Biological significance of α2,6-sialylation at the organism level as revealed using of the knockout medaka for the α2,6-sialyltransferades I and II genes
- 氏名:別所 美里(生命農学研究科修士1年)
受賞名:糖鎖科学中部拠点「若手の力フォーラム」 奨励賞
受賞年月日:2022年1月13日
対象演題:別所美里, 呉迪, 羽根正弥, 佐藤ちひろ, 北島健
後口動物CMP-シアル酸合成酵素の基質特異性と細胞内局在性の比較解析
- 氏名:中川 貴博(生命農学研究科修士2年)
受賞名: 令和3年度日本生化学会中部支部支部長賞
受賞年月日:2022年3月25日
- 氏名:大本 敬之(生命農学研究科博士3年 )
受賞名:第41回日本糖質学会年会 奨励賞
受賞年月日:2022年9月29日-10月1日
対象演題:メダカの生存に必須なα2,6-シアル酸担体タンパク質の同定と役
2021年
- 氏名:大本 敬之(生命農学研究科博士2年)
受賞名:第94回日本生化学会大会若手優秀発表賞
受賞年月日:2021年11月3-5日
対象演題:大本敬之、呉迪、橋本寿史、日比正彦、羽根正弥、佐藤ちひろ、北島健. α2,6-シアル酸転移酵素遺伝子のノックアウトメダカの表現型と糖鎖構造解析.
2020年
- 氏名:畑中 理菜(生命農学研究科修士2年)
受賞名:第93回日本生化学会大会若手優秀発表賞
受賞年月日:2020年9月14-16日
対象演題:畑中理菜、荒木映莉乃、羽根正弥、Wu Di、北島健、佐藤ちひろ.
オリゴシアル酸転移酵素ST8Sia6の発現はメラノーマを悪性化する.
- 氏名:大本 敬之(生命農学研究科博士1年)
受賞名:第21回比較グライコーム研究会2020・横浜onlineシンポ「糖の起源と進化〜宇宙 &深海〜」奨励賞
受賞年月日:2020年8月21日
対象演題:東山動植物園と協力するメダカのグライコミクス
- 氏名:大本 敬之(生命農学研究科博士1年)
受賞名:糖鎖科学中部拠点「若手の力フォーラム」 奨励賞
受賞年月日:2021年1月22日
対象演題: 大本敬之, 呉迪, 橋本寿史, 日比正彦, 羽根正弥, 佐藤ちひろ, 北島健. α2,6-シアル酸転移酵素遺伝子のノックアウトメダカの樹立と表現型の解析
2018年
- 受賞名:第91回日本生化学会大会 若手優秀発表賞
受賞年月日:2018年9月24日
対象演題:ポリシアル酸転移酵素 ST8SIA2 と ST8SIA4が合成するポリシアル酸の構造と性質.
○森愛理、羽根正弥、北島健、佐藤ちひろ.
学会発表(Conference)
【国際会議発表】 −招待講演、特別講演、シンポジウム講演以外は査読あり
20XX年
【国際学会】
講演
口頭発表
ポスター発表
【国内学会】
口頭発表
ポスター発表
【国内会議発表】−招待講演、特別講演、シンポジウム講演以外は査読あり
20XX年